{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:04:23Z","timestamp":1759104263826,"version":"3.38.0"},"reference-count":22,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine clinical, enzymatic, and\nmicrobiologic effects of controlled-release localized\nadministration of minocycline on dogs with periodontitis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014Five adult Beagles with periodontitis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014After tooth scaling and root planing, 2\ntreatment, 1 placebo, and 1 control site were selected\nfor each dog. Treatment sites (n = 10) received a\nperiodontal formulation of minocycline hydrochloride,\nplacebo sites (5) received ointment without minocycline,\nand control sites (5) did not receive ointment.\nTreatments were administered 4 times at weekly\nintervals. Peptidase activity and clinical and microbiologic\neffects were evaluated and compared among\nsites for 17 weeks.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Bleeding of the gums on probing (BOP) and\npocket depth (PD) improved at the treatment site and\nwere maintained for 13 weeks after treatment.\nHowever, BOP and PD in placebo and control sites\nincreased from weeks 9 to 17. Peptidase activity in\nthe periodontal pocket decreased noticeably from\nweek 1 to 17, compared with baseline values for the\ntreatment site. However, peptidase activity for placebo\nand control sites increased and were above baseline\nvalues on week 9 and week 13, respectively. Total\nbacterial counts decreased by 90% for treatment\nsites and remained at that value for 13 weeks.\nHowever, for placebo and control sites, bacterial\ncounts increased and reached the baseline value on\nweek 17.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Increased\npeptidase activity is correlated with the progression\nof periodontitis in dogs. Treatment with minocycline,\nusing a localized delivery system, was effective in\ndogs for at least 13 weeks after cessation of drug\nadministration. 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