{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T05:23:45Z","timestamp":1741411425251,"version":"3.38.0"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To characterize urodynamic function and\nanatomy before and after colposuspension in anesthetized\nfemale Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201412 adult female Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014During general anesthesia (thiopental\nsodium induction and halothane maintenance), urethral\npressure profiles, leak point pressure measurements\nwith a 50-ml bladder volume, positive contrast\ncystograms, and retrograde vaginourethrocystograms\nwere performed. A caudal midline laparotomy was\nused to perform colposuspension. Urodynamic and\nradiographic studies were repeated after surgery.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Leak point pressures were increased (120\nto 168.9 cm H<jats:sub>2<\/jats:sub>O), and maximum urethral closure\npressures decreased (43.7 to 19.3 cm H<jats:sub>2<\/jats:sub>O ) after colposuspension.\nThe urethra and bladder were moved\ncranially; the external urethral orifice was positioned\ncloser to the pelvic cavity, and the neck of the bladder\nwas positioned more cranially into the abdomen.\nLength of the urethra, as measured by use of vaginourethrocystograms,\nwas increased by 3%. As measured\nby use of urethral pressure profiles, total profile\nlength was increased by 19.9%, and functional profile\nlength was increased by 19.2%.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Increased\nleak-point pressure correlated with the expected clinical\nimprovement attributable to colposuspension.\nIncreased exposure of the urethra to abdominal and\npelvic cavity pressures may be the mechanism by\nwhich incontinent dogs become continent after colposuspension.\nResults of the leak-point pressure test\nmay correlate with clinical behavior before and after\ncolposuspension for treatment of incontinence. 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