{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:52:22Z","timestamp":1760079142722,"version":"3.38.0"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether increased conglutinin\ntiters are evident in stressed calves that do not\ndevelop respiratory tract disease in feedlots,compared\nwith respiratory tract disease, and to determine\nthe increase in immunoconglutinin titers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014101 mixed-breed beef calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Calves were processed at 4 farms of origin\nand allowed to remain with their dams for another\n100 days. Calves from each farm were brought to a\ncentrally located order-buyer barn. In a feedlot, 101\ncalves were assigned to pens and observed daily for\nclinical signs of acute respiratory tract disease. When\nsick calves were detected, they were treated with\nantibiotics and isolated in a pen for 4 days.\nConglutinin and immunoconglutinin titers were determined\nfor all calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014During the 28-day study, 73 calves developed\nrespiratory tract disease, whereas 28 calves\nremained healthy. Mean conglutinin titers differed significantly\namong calves from the 4 farms. Significant\ndifferences were not detected in conglutinin titers\namong calves on the basis of sex, morbidity, or vaccination\nstatus against <jats:italic>Mannheimia haemolytica<\/jats:italic> at\neach farm, the order-buyer barn, or the feedlot on\ndays 8, 15, and 28 after arrival. Immunoconglutinin\ntiters in calves differed significantly among farms and\nmorbidity status.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Mean conglutinin\ntiters in calves do not appear to be associated with\nthe incidence of acute respiratory tract disease; however,\nincreased immunoconglutinin titers appear to be\nassociated with recovery of stressed calves from respiratory\ntract disease during the first 15 days after\narrival in a feedlot. 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