{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:34:36Z","timestamp":1763746476129,"version":"3.38.0"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To measure and compare synovial fluid\nantibody titers to type-I and -II collagen in stifle joints\nwith instability caused by complete or partial cranial\ncruciate ligament (CCL) rupture and joints with\nosteoarthrosis secondary to other pathologic changes\nin dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201482 dogs with diseased stifle joints.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Synovial fluid samples were collected\nfrom 7 dogs with clinically normal stifles (control\ngroup) and 82 dogs with diseased joints (50 stifle\njoints with complete rupture of the CCL, 20 with partial\ndamage of the CCL, and 12 joints with radiographic\nsigns of osteoarthritis secondary to other\narthropathies). Synovial fluid samples were tested for\nautoantibodies to type-I and -II collagen by an ELISA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In dogs with complete and partial CCL rupture,\nsynovial fluid antibody titers to type-I and -II collagen\nwere significantly increased, compared with\ncontrol dogs. Forty-eight percent (24\/50) of samples\nfrom dogs with complete CCL rupture and 35% (7\/20)\nof samples from dogs with partial CCL rupture had\nantibody titers to type-I collagen that were greater\nthan the mean plus 2 standard deviations of the control\ngroup titers. Synovial fluid antibody titers to type-\nII collagen were high in 40% of the dogs with partial\nor (8\/20) complete (20\/50) CCL rupture. Dogs with\nosteoarthrosis secondary to other pathologic changes\nhad significantly increased synovial fluid antibodies to\ntype-I and -II collagen, compared with control dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion<\/jats:bold>\u2014Increases in autoantibodies to collagen\nin synovial fluid are not specific for the type of joint\ndisorder. It is unlikely that the anticollagen antibodies\nplay an active role in the initiation of weakening of the\nCCL. 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