{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:21:20Z","timestamp":1770218480593,"version":"3.49.0"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate intestinal permeability and\ngluten sensitivity in a family of Soft-Coated Wheaten\nTerriers (SCWT) affected with protein-losing\nenteropathy (PLE), protein-losing nephropathy (PLN),\nor both.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20146 affected adult dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Intestinal biopsy specimens, urine protein-\nto-creatinine ratio, serum concentrations of albumin\nand globulin, and concentration of \u03b1<jats:sub>1<\/jats:sub>-protease\ninhibitor in feces were evaluated before, during, and\n13 weeks after daily administration of 10 g of gluten\nfor 7 weeks. Eosinophils and lymphocytes-plasmacytes\nwere enumerated in intestinal biopsy specimens.\nIntestinal permeability was evaluated before\nand during the sixth week of gluten administration via\ncellobiose-mannitol and chromium-EDTA absorption\ntests.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Serum globulin concentration decreased significantly\nafter prolonged administration of gluten.\nAlthough not significant, there was an increase in lymphocytes-\nplasmacytes and a decrease in eosinophils in\nintestinal biopsy specimens. Furthermore, these counts\nwere greater than those reported for clinically normal\ndogs. Gluten administration did not increase intestinal\npermeability.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Daily administration\nof gluten was associated with a significant\ndecrease in serum globulin concentration in SCWT\naffected with PLE or PLN, but other variables\nremained unchanged. Although enhanced wheatgluten\nsensitivity may be one factor involved in the\npathogenesis of PLE or PLN in SCWT, this syndrome\ndoes not appear to be the result of a specific sensitivity\nto gluten. 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