{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:17:41Z","timestamp":1776125861612,"version":"3.50.1"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine clinical response and toxic\neffects of cis-bis-neodecanoato-trans-R,R-1,2-\ndiaminocyclohexane platinum (II) (L-NDDP) administered\nIV at escalating doses to cats with oral squamous\ncell carcinoma (SCC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201418 cats with oral SCC.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Cats that failed to respond to conventional\ntreatment or had nonresectable tumors were\nincluded. Data included a CBC, serum biochemical\nanalyses, urinalysis, cytologic examination of a fineneedle\naspirate of enlarged lymph nodes, and thoracic\nand oral radiographs for clinical staging. A\nstarting dose (75 to 100 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    of L-NDDP) was\nadministered IV. At 21-day intervals, subsequent\ndoses increased by the rate of 5 or 10 mg\/m\n                    <jats:sup>2<\/jats:sup>\n                    .\nResponse was evaluated every 21 days by tumor\nmeasurement and thoracic radiography. Quality of\nlife was assessed by owners, using a performance\nstatus questionnaire.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014On average, cats received 2 treatments.\nToxicoses included an intermittent, acute anaphylactoid-\nparasympathomimetic reaction, lethargy or\nsedation (\u2264 24 hours), inappetence or signs of\ndepression (\u2264 72 hours), mild to moderate increase\nin hepatic enzyme activity, and melena. Pulmonary,\nrenal, or hematopoietic abnormalities were not evident.\nPerformance status surveys indicated normal\nbehavior and grooming or decreased activity and\nself-care (19\/20 assessments), ate well with or\nwithout assistance (15\/20), and did not lose weight\n(15\/20). Median survival time was 59.8 days (mean,\n54.1 days).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014L-NDDP was\nineffective for treatment of cats with oral SCC. None\nof the cats had a complete or partial remission.\nAcute toxicoses and poor therapeutic response limit\ntherapeutic usefulness of L-NDDP in cats, unless\ndosage, frequency, and administration procedures\ncan be improved. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2000;61:\n791\u2013795)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2000.61.791","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T12:06:21Z","timestamp":1133870781000},"page":"791-795","source":"Crossref","is-referenced-by-count":41,"title":["Use of cis-bis-neodecanoato-trans-R,R-1, 2-diaminocyclohexane platinum (II), a liposomal cisplatin analogue, in cats with oral squamous cell carcinoma"],"prefix":"10.2460","volume":"61","author":[{"given":"Leslie E.","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula B.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Vail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart C.","family":"Helfand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Gregory","family":"MacEwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Perez-Soler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maron","family":"Calderwood-Mays","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilene D.","family":"Kurzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_315","first-page":"917","volume":"17","author":"Cotter SM","year":"1981","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_2_316","unstructured":"Couto CG. Oncology. In: Sherding RG, ed. The cat: diseases and clinical management. New York: Churchill Livingstone, 1989:629."},{"key":"p_3_317","first-page":"366","author":"Cotchin E.","year":"1984","journal-title":"Melbourne: Blackwell Scientific Publications"},{"key":"p_4_318","first-page":"406","author":"Carpenter JL","year":"1987","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_5_319","first-page":"438","volume":"29","author":"Postorino-Reeves NC","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_6_320","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/030098588902600204","volume":"26","author":"Stebbins KE","year":"1989","journal-title":"Vet Pathol"},{"key":"p_7_321","first-page":"277","author":"Withrow SJ","year":"1996","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_8_322","first-page":"273","volume":"19","author":"Withrow SJ","year":"1983","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_9_323","first-page":"606","author":"Turrel JM","year":"1987","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_10_324","first-page":"460","volume":"184","author":"Bradley RL","year":"1984","journal-title":"J Am Med Vet Assoc"},{"key":"p_11_325","first-page":"19","volume":"23","author":"Penwick RC","year":"1987","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_12_326","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0360-3016(91)90012-S","volume":"20","author":"Evans SM","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"p_13_327","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2460\/javma.1992.201.05.777","volume":"201","author":"Hutson CA","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"p_14_328","first-page":"574","author":"Schantz SP","year":"1993","journal-title":"Philadelphia: JB Lippincott Co"},{"key":"p_15_329","doi-asserted-by":"crossref","first-page":"704","DOI":"10.7326\/0003-4819-100-5-704","volume":"100","author":"Loeher PJ","year":"1984","journal-title":"Cisplatin. Ann Intern Med"},{"key":"p_16_330","doi-asserted-by":"publisher","DOI":"10.1007\/BF00144263"},{"key":"p_17_331","first-page":"471","volume":"66","author":"Kish JA","year":"1982","journal-title":"Cancer Treat Rep"},{"key":"p_18_332","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1939-1676.1987.tb01983.x","volume":"1","author":"Knapp DW","year":"1987","journal-title":"J Vet Intern Med"},{"key":"p_19_333","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1939-1676.1988.tb01976.x","volume":"2","author":"Knapp DW","year":"1988","journal-title":"J Vet Intern Med"},{"key":"p_20_334","first-page":"1575","volume":"189","author":"Himsel CA","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"p_21_335","first-page":"1530","volume":"193","author":"Shapiro W","year":"1988","journal-title":"J Am Vet Med Assoc"},{"key":"p_22_336","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(84)90035-4"},{"key":"p_23_337","first-page":"59","author":"Perez-Soler R","year":"1989","journal-title":"New York: Alan R. Liss Inc"},{"key":"p_24_338","doi-asserted-by":"publisher","DOI":"10.1007\/BF00451645"},{"key":"p_25_339","first-page":"4254","volume":"50","author":"Perez-Soler R","year":"1990","journal-title":"Cancer Res"},{"key":"p_26_340","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254097"},{"key":"p_27_341","first-page":"6462","volume":"47","author":"Perez-Soler R","year":"1987","journal-title":"Cancer Res"},{"key":"p_28_342","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2460\/ajvr.1999.60.02.257","volume":"60","author":"Fox LE","year":"1999","journal-title":"Am J Vet Res."},{"key":"p_29_343","first-page":"463","author":"Owen LN","year":"1996","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_30_344","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","volume":"53","author":"Kaplan EF","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"p_31_345","unstructured":"Dixon WJ. Survival analysis. In: BMDP Statistical Software. Berkeley: University of California Press, 1981:557-585."},{"key":"p_32_346","first-page":"499","author":"Theilen GH","year":"1987","journal-title":"Philadelphia: Lea and Febiger"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/61\/7\/ajvr.2000.61.791.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/61\/7\/ajvr.2000.61.791.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/61\/7\/ajvr.2000.61.791.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:08:42Z","timestamp":1775765322000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/61\/7\/ajvr.2000.61.791.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":32,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2000.61.791","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7,1]]}}}