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Two\ndogs not exposed to ticks were treated with dexamethasone\nand served as negative-control dogs.\nClinical signs, results of microbial culture and polymerase\nchain reaction (PCR) testing, immunologic\nresponses, and gross and histologic lesions were\nevaluated 9 months after tick exposure.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Predominant clinical signs were episodic\npyrexia and lameness in 12 of 20 dogs. Infection with\n<jats:italic>B burgdorferi <\/jats:italic>was detected in microbial cultures of\nskin biopsy specimens and various tissues obtained\nduring necropsy in 19 of 20 dogs and in all 20 dogs by\nuse of a PCR assay. All 20 exposed dogs seroconverted\nand developed chronic nonsuppurative arthritis.\nThree dogs also developed mild focal meningitis,\n1 dog developed mild focal encephalitis, and 18 dogs\ndeveloped perineuritis or rare neuritis. Control dogs\nwere seronegative, had negative results for microbial\nculture and PCR testing, and did not develop lesions.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Use of this\ntechnique successfully induced borreliosis in young\ndogs. Dogs with experimentally induced borreliosis\nmay be useful in evaluating vaccines, chemotherapeutic\nagents, and the pathogenesis of borreliosisinduced\narthritis. 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