{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T05:50:46Z","timestamp":1757310646350,"version":"3.38.0"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To identify the major allergenic proteins\nfrom the 3 main species of dust mites to which dogs\nreact (<jats:italic>Dermatophagoides farinae, D pteronyssinus,<\/jats:italic>and\n<jats:italic>Euroglyphus maynei<\/jats:italic>) and evaluate the potential crossreactivity\nof dust mite allergens with antigens from the\nectoparasitic mite <jats:italic>Sarcoptes scabiei<\/jats:italic> var <jats:italic>canis<\/jats:italic>.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014Sera from 83 dogs with atopic\ndermatitis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Sodium dodecylsulfate-polyacrylamide\ngel electrophoresis and immunoblotting using serum\nfrom atopic dogs was used to identify IgE-binding proteins\nin extracts of the 4 mite species.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Sera of atopic dogs contained IgE against\n23, 17, 25, and 17 allergens from <jats:italic>D farinae,\nD pteronyssinus, E maynei,<\/jats:italic>and<jats:italic> S scabiei,<\/jats:italic> respectively.\nUnlike the situation for humans, the major allergens\nfor dogs are mostly proteins that are larger than\n90 kd molecular weight. <jats:italic>Dermatophagoides farinae<\/jats:italic>\nand <jats:italic>E maynei<\/jats:italic> appear to be more allergenic for dogs\nthan is <jats:italic>D pteronyssinus<\/jats:italic>. Some dogs with serum IgE\nagainst dust mites also had IgE against antigens of\n<jats:italic>S scabiei<\/jats:italic> var <jats:italic>canis<\/jats:italic>.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Multiple dust\nmite allergens induce an IgE response in dogs. These\nallergens are mostly greater than 90 kd molecular\nweight. (<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:1344\u20131348)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.1344","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:20:00Z","timestamp":1133889600000},"page":"1344-1348","source":"Crossref","is-referenced-by-count":14,"title":["Characterization of house dust mite and scabiesmite allergens by use of canine serum antibodies"],"prefix":"10.2460","volume":"62","author":[{"given":"R. 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