{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:59:34Z","timestamp":1774130374060,"version":"3.50.1"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate viral and bacterial respiratory\npathogens and <jats:italic>Mycoplasma<\/jats:italic> spp isolated from lung\ntissues of cattle with acute interstitial pneumonia (AIP)\nand cattle that had died as a result of other causes.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014186 samples of lung tissues\ncollected from cattle housed in 14 feedlots in the\nwestern United States.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Lung tissues were collected during routine\npostmortem examination and submitted for histologic,\nmicrobiologic, and toxicologic examinations.\nHistologic diagnoses were categorized for AIP, bronchopneumonia\n(BP), control samples (no evidence of\ndisease), and other disorders.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Cattle affected with AIP had been in feedlots\nfor a mean of 127.2 days before death, which was\nlonger than cattle with BP and control cattle.\nDetection of a viral respiratory pathogen (eg, bovine\nrespiratory syncytial virus [BRSV], bovine viral diarrhea\nvirus, bovine herpesvirus 1, or parainfluenza\nvirus 3) was not associated with histologic category\nof lung tissues. Bovine respiratory syncytial virus was\ndetected in 8.3% of AIP samples and 24.0% of control\nsamples. Histologic category was associated with\nisolation of an aerobic bacterial agent and\n<jats:italic>Mycoplasma<\/jats:italic> spp. Cattle with BP were at greatest risk\nfor isolation of an aerobic bacterial agent and\n<jats:italic>Mycoplasma<\/jats:italic> spp.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Analysis of\nthese results suggests that AIP in feedlot cattle is not\na consequence of infection with BRSV. The increased\nrisk of isolation of an aerobic bacterial agent from cattle\nwith AIP, compared with control cattle, may indicate\na causal role or an opportunistic infection that follows\ndevelopment of AIP. 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