{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:02:01Z","timestamp":1770069721915,"version":"3.49.0"},"reference-count":42,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To characterize the change of pH in the\nabomasal lumen throughout a 24-hour period, to\ndetermine whether pH of the abomasal body differs\nfrom pH of the pyloric antrum, and to determine\nwhether oral administration of cimetidine and ranitidine\nalters pH of the abomasal lumen in milk-fed\ncalves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20145 male dairy calves (4 Holsteins-Friesian, 1\nAyrshire), 5 to 15 days old.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cannulas were surgically positioned in\nthe abomasal body and pyloric antrum of each calf.\nCalves received the following treatments in a randomized\ncrossover design: milk replacer (60 ml\/kg of\nbody weight, q 12 h [untreated control calves]), milk\nreplacer and cimetidine (50 or 100 mg\/kg, q 8 h), or\nmilk replacer and ranitidine (10 or 50 mg\/kg, q 8 h).\nThe pH of the abomasal body and pyloric antrum was\nmeasured for 24 hours, using miniature glass pH electrodes.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Suckling of milk replacer immediately\nincreased abomasal luminal pH from 1.4 to 6.0, followed\nby a gradual decrease to preprandial values by\n6 hours. Preprandial and postprandial pH values were\nnot significantly different between the abomasal body\nand pyloric antrum, indicating lack of pH compartmentalization\nin the abomasum of milk-fed calves.\nAdministration of cimetidine and ranitidine caused a\nsignificant dose-dependent increase in mean 24-hour\nabomasal luminal pH.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Abomasal acid\nsecretion in milk-fed calves is mediated in part by histamine\ntype-2 receptors. Cimetidine and ranitidine may\nbe efficacious in the treatment of abomasal ulcers in\nmilk-fed calves. 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