{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:16:19Z","timestamp":1769674579653,"version":"3.49.0"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether infection with\n<jats:italic>Tritrichomonas foetus<\/jats:italic> causes diarrhea in specific pathogen-free or <jats:italic>Cryptosporidium<\/jats:italic> coinfected cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20144 cats with subclinical cryptosporidiosis\n(group 1) and 4 specific-pathogen-free cats (group 2).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cats were infected orogastrically with an\naxenic culture of <jats:italic>T foetus<\/jats:italic> isolated from a kitten with\ndiarrhea. Direct microscopy and protozoal culture of\nfeces, fecal character, serial colonic mucosal biopsy\nspecimens, and response to treatment with nitazoxanide\n(NTZ; group 1) or prednisolone (groups 1 and 2)\nwere assessed.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Infection with <jats:italic>T foetus<\/jats:italic> persisted in all cats\nfor the entire 203-day study and resulted in diarrhea\nthat resolved after 7 weeks. Group-1 cats had an earlier\nonset, more severe diarrhea, and increased number\nof trichomonads on direct fecal examination, compared\nwith group-2 cats. Use of NTZ eliminated shedding\nof <jats:italic>T foetus<\/jats:italic> and <jats:italic>Cryptosporidium<\/jats:italic> oocysts, but\ndiarrhea consisting of trichomonad-containing feces\nrecurred when treatment was discontinued.\nPrednisolone did not have an effect on infection with\n<jats:italic>T foetus<\/jats:italic> but resulted in reappearance of\n<jats:italic>Cryptosporidium<\/jats:italic> oocysts in the feces of 2 of 4 cats.\nDuring necropsy, <jats:italic>T foetus <\/jats:italic>was isolated from contents\nof the ileum, cecum, and colon. <jats:italic>Tritrichomonas foetus<\/jats:italic>\norganisms and antigen were detected on surface\nepithelia and within superficial detritus of the cecal\nand colonic mucosa.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014After experimental\ninoculation in cats, <jats:italic>T foetus<\/jats:italic> organisms colonize\nthe ileum, cecum, and colon, reside in close contact\nwith the epithelium, and are associated with transient\ndiarrhea that is exacerbated by coexisting cryptosporidiosis\nbut not treatment with prednisolone.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:1690\u20131697)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.1690","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:28:43Z","timestamp":1133890123000},"page":"1690-1697","source":"Crossref","is-referenced-by-count":100,"title":["Experimental infection of cats with Tritrichomonas foetus"],"prefix":"10.2460","volume":"62","author":[{"given":"Jody L.","family":"Gookin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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