{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:53:50Z","timestamp":1770216830689,"version":"3.49.0"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effects of a low or high\nsodium (Na) diet with or without furosemide administration\non plasma electrolyte concentrations and the\nrenin-angiotensin-aldosterone system in healthy\ndogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 healthy adult dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were randomly allotted to 4 groups\nof 5 dogs each as follows: dogs fed a low Na diet\n(0.08% Na and 0.8% chloride [Cl] on a dry matter\n[DM] basis); dogs fed a low Na diet with added NaCl\n(1.0% Na and 2.2% Cl on a DM basis); dogs fed a low\nNa diet and treated with furosemide (2 mg\/kg of body\nweight, PO, q 12 h); and dogs fed a low Na diet with\nadded NaCl and treated with furosemide. Plasma\nelectrolyte concentrations were measured on days 0,\n21, and 35. Plasma renin activity and aldosterone concentration\nwere analyzed by use of radioimmunoassays\non days 0, 21, 35, and 53.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Furosemide treatment significantly decreased\nplasma Cl concentration and significantly\nincreased plasma renin activity and aldosterone concentration.\nDogs fed a low Na diet had significantly\nhigher plasma renin activities and plasma aldosterone\nconcentrations. A significant interaction between a\nlow Na diet and furosemide administration resulted in\nthe lowest plasma Cl concentrations, highest plasma\nrenin activities, and highest plasma aldosterone concentrations.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In healthy\ndogs, feeding a low Na diet and administering\nfurosemide resulted in an additive effect on plasma Cl\nconcentration, renin activity, and aldosterone concentration,\nwhich may be an important consideration for\ntreating dogs with cardiac disease. 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