{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:21:51Z","timestamp":1781356911527,"version":"3.54.1"},"reference-count":53,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To examine the effects of an aerosolized\n\u03b2<jats:sub>2<\/jats:sub>-adrenoreceptor agonist, albuterol, on performance\nduring a standardized incremental exercise test in\nclinically normal horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 Standardbred pacing mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Clinically normal horses, as judged by\nuse of physical examination, hematologic findings,\nserum biochemical analysis, and airway endoscopy,\nwere randomly assigned to 2 groups and were given\n900 \u00b5g of albuterol via a metered-dose inhaler 30 minutes\nbefore beginning a standardized incremental\nexercise test in a crossover design with a 7-day minimum\nwashout. Further examination included measurement\nof baseline lung mechanics, response to\nhistamine bronchoprovocation, and bronchoalveolar\nlavage.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014No significant differences (albuterol vs\nplacebo) were seen for any incremental exercise test\nvariables (ie, maximum oxygen consumption, maximum\ncarbon dioxide consumption, respiratory quotient,\ntreadmill speed at heart rate of 200 beats\/min,\nor number of steps completed during an incremental\nexercise protocol). Mast cell percentage was significantly\n(<jats:italic>r<\/jats:italic> = \u20130.84) associated with the concentration of\naerosolized histamine that evoked a 100% increase in\ntotal respiratory system resistance. No other direct\ncorrelations between bronchoalveolar lavage fluid cell\ntypes and any indices of exercise capacity or airway\nreactivity were found.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Although no\nhorse had exercise intolerance, 4 horses had airway\nhyperreactivity with bronchoalveolar lavage fluid mastocytosis;\nthese horses may have been subclinically\naffected with inflammatory airway disease. In our\nstudy, albuterol did not enhance performance in 8 clinically\nnormal racing-fit Standardbreds. 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