{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:12Z","timestamp":1787025252730,"version":"build-2736575974"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:bold>\n \u2014To evaluate the use of an intravitreal sustained-release cyclosporine (CsA) delivery device for treatment of horses with naturally occurring recurrent uveitis.\n <\/jats:p>\n \n Animals<\/jats:bold>\n \u201416 horses with recurrent uveitis.\n <\/jats:p>\n \n Procedures<\/jats:bold>\n \u2014Horses with frequent recurrent\nepisodes of uveitis or with disease that was progressing\ndespite appropriate medication were selected\nfor this study. Additional inclusion criteria included\nadequate retinal function as determined by use of\nelectroretinography, lack of severe cataract formation,\nand no vision-threatening ocular complications (eg,\nretinal detachment, severe retinal degeneration, and\nposterior synechia). Sustained-release CsA delivery\ndevices (4 \u00b5g of CsA\/d) were implanted into the vitreous\nthrough a sclerotomy at the pars plana.\nReexaminations were performed 1, 3, 6, and 12\nmonths after implantation, then continued annually.\nOphthalmic changes, number of recurrent episodes\nof uveitis, and vision were recorded.\n <\/jats:p>\n \n Results<\/jats:bold>\n \u2014The rate of recurrent episodes after device\nimplantation (0.36 episodes\/y) was less than prior to\nsurgery (7.5 episodes\/y). In addition, only 3 horses\ndeveloped episodes of recurrent uveitis after surgery.\nVision was detected in 14 of 16 affected eyes at a\nmean follow-up time of 13.8 months (range, 6 to 24\nmonths).\n <\/jats:p>\n \n Conclusions and Clinical Relevance<\/jats:bold>\n \u2014This intravitreal\nsustained-release CsA delivery device may be a\nsafe and important tool for long-term treatment of\nhorses with chronic recurrent uveitis. (\n Am J Vet Res<\/jats:italic>\n 2001;62:1892\u20131896)\n <\/jats:p>","DOI":"10.2460\/ajvr.2001.62.1892","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T12:34:36Z","timestamp":1133872476000},"page":"1892-1896","source":"Crossref","is-referenced-by-count":46,"title":["Use of an intravitreal sustained-release cyclosporine delivery device for treatment of equine recurrent uveitis"],"prefix":"10.2460","volume":"62","author":[{"given":"Brian C.","family":"Gilger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Wilkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice B.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_268","first-page":"27","volume":"12","author":"Abrams KL","year":"1990","journal-title":"Equine Pract"},{"key":"p_2_269","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0749-0739(17)30441-8","volume":"8","author":"Schwink KL","year":"1992","journal-title":"Vet Clin North Am Equine Pract"},{"key":"p_3_270","first-page":"593","author":"Davidson MG","year":"1992","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_4_271","first-page":"351","volume":"8","author":"Miller TR","year":"1987","journal-title":"Mod Vet Pract"},{"key":"p_5_272","first-page":"803","volume":"175","author":"Rebhun WC","year":"1979","journal-title":"J Am Vet Med Assoc"},{"key":"p_6_273","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(99)00082-3"},{"key":"p_7_274","doi-asserted-by":"crossref","unstructured":"Kay JE. 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