{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:28:32Z","timestamp":1778279312402,"version":"3.51.4"},"reference-count":43,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess the influence of preanesthetic\nadministration of acetylpromazine or morphine and\nfluids on urine production, arginine vasopressin (AVP;\npreviously known as antidiuretic hormone) concentrations,\nmean arterial blood pressure (MAP), plasma\nosmolality (Osm), PCV, and concentration of total\nsolids (TS) during anesthesia and surgery in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201419 adult dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Concentration of AVP, indirect MAP,\nOsm, PCV, and concentration of TS were measured at\n5 time points (before administration of acetylpromazine\nor morphine, after administration of those\ndrugs, after induction of anesthesia, 1 hour after the\nstart of surgery, and 2 hours after the start of\nsurgery). Urine output and end-tidal halothane concentrations\nwere measured 1 and 2 hours after the\nstart of surgery. All dogs were administered lactated\nRinger's solution (20 ml\/kg of body weight\/h, IV) during\nsurgery.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Compared with values for acetylpromazine,\npreoperative administration of morphine resulted in\nsignificantly lower urine output during the surgical\nperiod. Groups did not differ significantly for AVP concentration,\nOsm, MAP, and end-tidal halothane concentration;\nhowever, PCV and concentration of TS\ndecreased over time in both groups and were lower in\ndogs given acetylpromazine.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Preanesthetic\nadministration of morphine resulted in significantly\nlower urine output, compared with values after\nadministration of acetylpromazine, which cannot be\nexplained by differences in AVP concentration or MAP.\nWhen urine output is used as a guide for determining\nrate for IV administration of fluids in the perioperative\nperiod, the type of preanesthetic agent used must be\nconsidered.(<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:1922\u20131927)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.1922","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:34:36Z","timestamp":1133890476000},"page":"1922-1927","source":"Crossref","is-referenced-by-count":18,"title":["Effects of acetylpromazine or morphine on urine production in halothane-anesthetized dogs"],"prefix":"10.2460","volume":"62","author":[{"given":"Sheilah A.","family":"Robertson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph G.","family":"Hauptman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ray F.","family":"Nachreiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlee 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