{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:07Z","timestamp":1785577207233,"version":"3.56.0"},"reference-count":58,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effect of 0.005%\nlatanoprost solution on intraocular pressure (IOP) of\neyes of clinically normal horses and establish the frequency\nof adverse effects of drug administration.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 adult clinically normal horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014IOP was recorded (7, 9, and 11 AM; 3, 5,\nand 7 PM) on days 1 and 2 (baseline), days 3 to 7 (treatment),\nand days 8 to 9 (follow-up). Latanoprost was\nadministered to 1 randomly assigned eye of each\nhorse every 24 hours during the treatment period, following\nthe 7 AM IOP recording. Pupil size and the\npresence or absence of conjunctival hyperemia,\nepiphora, blepharospasm, blepharedema, and aqueous\nflare were recorded prior to IOP measurement.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014IOP was reduced from baseline by a mean\nvalue of 1.03 mm Hg (5%) in males and 3.01 mm Hg\n(17%) in females during the treatment period. Miosis\ndeveloped in all treated eyes and was moderate to\nmarked in 77% of horses, with the peak effect\nobserved 4 to 8 hours after drug administration.\nConjunctival hyperemia, epiphora, blepharospasm,\nand blepharedema were present in 100, 57, 42, and\n12% of treated eyes, respectively, 2 to 24 hours following\ndrug administration. Aqueous flare was not\nobserved at any time point.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Although IOP\nwas reduced with every 24-hour dosing of\nlatanoprost, the frequency of prostaglandin-induced\nadverse events was high. Because recurrent uveitis\nappears to be a risk factor for glaucoma in horses,\ntopical administration of latanoprost may potentiate\nprostaglandin-mediated inflammatory disease in\naffected horses. (<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:1945\u20131951)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.1945","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:34:36Z","timestamp":1133890476000},"page":"1945-1951","source":"Crossref","is-referenced-by-count":38,"title":["Effects of topical administration of 0.005% latanoprost solution on eyes of clinically normal horses"],"prefix":"10.2460","volume":"62","author":[{"given":"A. 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