{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:38:52Z","timestamp":1771943932592,"version":"3.50.1"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether intraluminal distention\nand subsequent decompression of the equine\njejunum affects intestinal blood flow, hemodynamics,\nand microvascular permeability.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20145 healthy adult horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Horses were anesthestized and underwent\nexploratory laparotomy. Two jejunal segments\nwere identified as sham-operated or instrumented\nsegments. After baseline values were obtained, intraluminal\ndistention was created in the experimental\nsegment to induce an intraluminal pressure of 18 cm\nH<jats:sub>2<\/jats:sub>O. After 120 minutes of distention, the intestine\nwas decompressed for 120 minutes. Mesenteric\nblood flow, oxygen delivery, oxygen consumption,\nmicrovascular permeability, wet weight-to-dry weight\nratio, neutrophil infiltration, and vascular resistance\nwere determined and comparisons made among control,\nsham-operated, and experimental segments.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Mean jejunal blood flow was 21.4 ml\/min\nper kg. There was a significant decrease in mesenteric\nblood flow to the distended intestine (13.4\nml\/min per kg). Blood flow increased significantly during\nthe decompression period (340% of baseline\nblood flow). Intraluminal distention and subsequent\ndecompression resulted in a significant increase in\nmicrovascular permeability, as determined by the\nosmotic reflection coefficient. Oxygen delivery and\noxygen content decreased significantly during the distention\nperiod and increased during decompression.\nMorphologic evaluation revealed a significant\nincrease in edema and neutrophil infiltration after distention\nand decompression, compared with results\nfor the sham-operated or control segments.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Intraluminal\ndistention and decompression of the equine jejunum\nresults in low-flow ischemia and edema, which may\ncontribute to adhesions and ileus in the postoperative\nperiod after surgery for obstructions of the small\nintestines. 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