{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:25:52Z","timestamp":1770218752079,"version":"3.49.0"},"reference-count":42,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine effects of the angiotensin\nconverting enzyme inhibitor benazepril in cats with\ninduced renal insufficiency.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201432 cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Renal mass was surgically reduced, and\ncats were assigned to 1 of 4 eight-cat groups. Group\n1 received placebo, whereas groups 2, 3, and 4\nreceived benazepril hydrochloride orally once daily for\napproximately 6.5 months at the following doses:\ngroup 2, 0.25 to 0.50 mg\/kg of body weight; group 3,\n0.50 to 1.00 mg\/kg; and group 4, 1.00 to 2.00 mg\/kg.\nArterial blood pressures, glomerular filtration rate\n(GFR), and renal plasma flow were determined before\ntreatment and during the treatment period. Other\ndeterminants of renal hemodynamics were measured\nby use of micropuncture techniques. Renal biopsy\nspecimens were examined microscopically.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Compared with cats that received placebo,\nmean systolic arterial blood pressure was significantly\nless and GFR significantly greater in cats that\nreceived benazepril. Glomerular capillary pressure\nand the ratio of efferent to afferent arteriolar vascular\nresistance were also significantly less in treated cats.\nHowever, histologic differences in renal specimens\nwere not detected.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Treatment\nwith benazepril sustained single nephron GFR in remnant\nnephrons of cats with induced renal insufficiency.\nAdministration of benazepril was also associated\nwith a small but significant reduction in degree of systemic\nhypertension and an increase in whole kidney\nGFR. Benazepril may be an effective treatment to\nslow the rate of progression of renal failure in cats\nwith renal disease. 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