{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:11:55Z","timestamp":1767852715345,"version":"3.49.0"},"reference-count":36,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To document uterine growth and microvascular\ndevelopment in the endometrium of uteri with differing\ndegrees of fibrosis as well as uterine growth\nthroughout the estrous cycle of mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201430 mares.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Uterine tissue was obtained during the\nbreeding season from a slaughter facility. Stage of\nestrous cycle of the mares was assessed on the basis\nof ovarian structures and plasma progesterone concentrations.\nEndometrium was characterized by use of light\nmicroscopy, and blood vessel walls were marked by histochemical\ntechniques. Microvascular development\nwas evaluated by a computerized image analysis system.\nGrowth of uterine tissue was based on cellular\ncontent of DNA and RNA, RNA:DNA, and protein:DNA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Significant differences in vascular density\nwere not observed in the endometrium of uteri\nobtained from mares euthanatized during the follicular\nor luteal phase of the estrous cycle, regardless of\nwhether endometrial classification of degree of fibrosis\nwas considered. There was a 3-fold increase in amount\nof DNA and RNA of endometrial cells in the follicular\nphase when compared to myometrium. Hypertrophy of\nendometrial tissue during the luteal phase was reflected\nby a significant increase in cell protein content and\nprotein:DNA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Endometrial\ngrowth of vascular tissues during the estrous cycle may\nbe coordinated with development of nonvascular tissue.\nEstrogen and progesterone may play a role in regulation\nof uterine growth and angiogenesis. 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New York: Raven Press, 1988;675-724."},{"key":"p_8_307","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1530\/jrf.0.0850747","volume":"85","author":"Brigstock DR","year":"1989","journal-title":"J Reprod Fertil"},{"key":"p_9_308","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1210\/edrv-11-2-266","volume":"11","author":"Clarke CL","year":"1990","journal-title":"Endocr Rev"},{"key":"p_10_309","first-page":"226","author":"Evans JW","year":"1982","journal-title":"Tex: Equine Research Publications"},{"key":"p_11_310","first-page":"700","volume":"189","author":"Liu IM","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"p_12_311","first-page":"241","volume":"172","author":"Kenney RM","year":"1978","journal-title":"J Am Vet Med Assoc"},{"key":"p_13_312","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.2042-3306.1991.tb02751.x","volume":"23","author":"Ricketts SW","year":"1991","journal-title":"Equine Vet J"},{"key":"p_14_313","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0021-9975(98)80051-0","volume":"119","author":"Gruninger B","year":"1998","journal-title":"J Comp Pathol"},{"key":"p_15_314","unstructured":"Klug E, Schoon HA, Schoon D. Contribution of uterine angiopathies to equine endometritis and endometriosis, in Proceedings. 3rd Conf Eur Soc Domest Anim Reprod 1999;29-30."},{"key":"p_16_315","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/jrf.0.1120049","volume":"112","author":"Lennard SN","year":"1998","journal-title":"J Reprod Fertil"},{"key":"p_17_316","first-page":"165","volume":"6","author":"Beier HM","year":"1971","journal-title":"Adv Biosci"},{"key":"p_18_317","first-page":"287","volume":"27","author":"Roberts RM","year":"1988","journal-title":"J Reprod Fertil"},{"key":"p_19_318","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.2460\/ajvr.1994.55.08.1060","volume":"55","author":"Ferreira-Dias G","year":"1994","journal-title":"Am J Vet Res"},{"key":"p_20_319","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2460\/ajvr.1999.60.01.49","volume":"60","author":"Ferreira-Dias G","year":"1999","journal-title":"Am J Vet Res"},{"key":"p_21_320","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2527\/jas1981.521119x","volume":"52","author":"Wesson JA","year":"1981","journal-title":"J Anim Sci"},{"key":"p_22_321","first-page":"207","volume":"23","author":"Geschwind II","year":"1975","journal-title":"J Reprod Fertil Suppl"},{"key":"p_23_322","first-page":"233","author":"Ginther OJ","year":"1992","journal-title":"Wis: Equiservices"},{"key":"p_24_323","first-page":"364","author":"Luna LG","year":"1992","journal-title":"Md: American Histolabs Inc"},{"key":"p_25_324","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod47.5.698"},{"key":"p_26_325","unstructured":"Baserga R. Tissue growth. In: Baserga R, ed. The biology of cell reproduction. Cambridge, Mass: University Press, 1985;46-58."},{"key":"p_27_326","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod56.2.393"},{"key":"p_28_327","first-page":"695","volume":"44","author":"Keenan LR","year":"1991","journal-title":"J Reprod Fertil Suppl"},{"key":"p_29_328","unstructured":"Reynolds LP, Killilea SD, Redmer DA. Endometrial growth and vascular development: patterns and mediators. In: Alexander NJ, D'Arcangues C, eds. Steroid hormones and uterine bleeding. New York: American Association for the Advancement of Science Press, 1992;37-48."},{"key":"p_30_329","first-page":"241","author":"Meschia G","year":"1983","journal-title":"Md: American Physiological Society"},{"key":"p_31_330","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.10.4511"},{"key":"p_32_331","unstructured":"Eickstein P, Zuckerman S. Changes in the accessory reproductive organs of the non-pregnant female. In: Parkes AS, ed. Marshall's physiology of reproduction. 2nd ed. Vol 1. 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