{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:20:40Z","timestamp":1778170840897,"version":"3.51.4"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess a point-of-care instrument for\nidentification of primary hemostatic disorders in dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201429 healthy dogs and 23 nonanemic dogs\nwith primary hemostatic disorders (thrombocytopenia,\nn = 6; thrombopathia, 6; von Willebrand disease\n[vWD], 11).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Citrated blood was obtained and closure\ntimes (CT) were determined by measuring the time\nrequired for occlusion of an aperture by a platelet plug\nwithin the point-of-care instrument. Reference ranges\nfor CT were established, and CT were determined for\ndogs with primary hemostatic disorders.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014CT measured with adenosine diphosphate\nas the platelet agonist (ADP-CT) ranged from 52 to 86\nseconds for healthy dogs (mean \u00b1 2 SD, 67 \u00b1 7.8 seconds;\nmedian, 65 seconds), and CT measured with\nepinephrine as the agonist (EPI-CT), from 97 to 225\nseconds (151 \u00b1 38 seconds; 148 seconds). In thrombocytopenic\ndogs, ADP- and EPI-CT were prolonged\n(&gt; 165 and &gt; 264 seconds, respectively). Five of 6\ndogs with thrombopathia had prolonged ADP-CT,\nwhereas EPI-CT was prolonged in all 6 dogs. In all\ndogs with vWD, ADP-CT was prolonged; EPI-CT was\nprolonged in 10 of these dogs. Sensitivity and specificity\nfor ADP-CT were 95.7 and 100%, respectively,\nand positive and negative predictive values, 100 and\n96.7%, respectively, whereas for EPI-CT, these values\nwere 95.7 and 82.8%, respectively, and 81.5 and\n96%, respectively.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014The point-ofcare\ninstrument allowed quick assessment of primary\nhemostasis in nonanemic dogs. Use of this instrument\nmay be helpful for making decisions regarding\nmanagement of dogs with primary hemostatic disorders.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:652\u2013658)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.652","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:28:14Z","timestamp":1133890094000},"page":"652-658","source":"Crossref","is-referenced-by-count":76,"title":["Assessment of a point-of-care instrument for identification of primary hemostatic disorders in dogs"],"prefix":"10.2460","volume":"62","author":[{"given":"Mary Beth","family":"Callan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Giger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_1","first-page":"81","author":"Tvedten H","year":"1994","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_2_2","unstructured":"Giger U, Brooks M, Dodds WJ, etalAdvances in canine von Willebrand disease, in Proceedings. 18th Annu Meet Vet Med Forum 2000;481-482."},{"key":"p_3_3","first-page":"1337","volume":"48","author":"Jergens AE","year":"1987","journal-title":"Am J Vet Res"},{"key":"p_4_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1055\/s-0037-1614362","volume":"82","author":"Cattaneo M","year":"1999","journal-title":"Thromb Haemost"},{"key":"p_5_5","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1182\/blood.V91.4.1325","volume":"91","author":"Fressinaud E","year":"1998","journal-title":"Blood"},{"key":"p_6_6","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(99)00152-8"},{"key":"p_7_7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-2007-995840","volume":"24","author":"Mammen EF","year":"1998","journal-title":"Semin Thromb Hemost"},{"key":"p_8_8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00001721-199901000-00004","volume":"10","author":"Harrison P","year":"1999","journal-title":"Blood Coagul Fibrinolysis"},{"key":"p_9_9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199911)62:3<165::AID-AJH6>3.0.CO;2-C"},{"key":"p_10_10","first-page":"1778","author":"Bennett JS","year":"1990","journal-title":"New York: McGraw-Hill Book Co"},{"key":"p_11_11","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1055\/s-0038-1649853","volume":"74","author":"Callan MB","year":"1995","journal-title":"Thromb Haemost"},{"key":"p_12_12","first-page":"106","volume":"21","author":"Kundu SK","year":"1995","journal-title":"Semin Thromb Hemost"},{"key":"p_13_13","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/107602969600200404","volume":"2","author":"Kundu SK","year":"1996","journal-title":"Clin Appl Thromb\/Hemost"},{"key":"p_14_14","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1055\/s-0038-1649669","volume":"70","author":"Brooks M","year":"1993","journal-title":"Thromb Haemost"},{"key":"p_15_15","first-page":"27","author":"Catalfamo JL","year":"1989","journal-title":"San Diego: Academic Press Inc"},{"key":"p_16_16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1748-5827.1994.tb03921.x","volume":"35","author":"Eksell P","year":"1994","journal-title":"J Small Anim Pract"},{"key":"p_17_17","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/vr.135.12.281","volume":"135","author":"Brown SJ","year":"1994","journal-title":"Vet Rec"},{"key":"p_18_18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5326\/15473317-33-5-411","volume":"33","author":"Smedile LE","year":"1997","journal-title":"J Am Anim Hosp Assoc"},{"key":"p_19_19","doi-asserted-by":"crossref","unstructured":"Callan MB, Walton R, Jezyk PF, etalThrombopathias causing bleeding in a Boxer and mixed breed dog.J Am Anim Hosp Assoc2001;37:in press.","DOI":"10.5326\/15473317-37-3-244"},{"key":"p_20_20","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-581"},{"key":"p_21_21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1939-1676.1994.tb03204.x","volume":"8","author":"Boudreaux MK","year":"1994","journal-title":"J Vet Intern Med"},{"key":"p_22_22","doi-asserted-by":"crossref","unstructured":"Boudreaux MK, Lipscomb DL. 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