{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:39:26Z","timestamp":1785577166374,"version":"3.56.0"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of topical administration\nof 2% dorzolamide hydrochloride or 2% dorzolamide\nhydrochloride-0.5% timolol maleate on intraocular\npressure (IOP) in clinically normal horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201418 healthy adult horses without ocular\nabnormalities.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014The IOP was measured at 5 time points\n(7 AM, 9 AM, 11 AM, 3 PM, 7 PM) over 11 days. On days\n1 and 2, baseline values were established. On days 3\nthrough 5, horses received 2% dorzolamide HCl\n(group D, n = 9) or 2% dorzolamide HCl-0.5% timolol\nmaleate (group DT, 9) in 1 randomly assigned eye\nevery 24 hours immediately following each daily 7 AM\nIOP measurement. On days 6 through 9, each drug\nwas given every 12 hours (7 AM and 7 PM) in the treated\neye. Measurements on days 10 and 11 assessed\nreturn to baseline. Mixed linear regression models\ncompared mean IOP difference for each drug at each\ntime period.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Mean IOP decreased significantly in all\neyes during the 2 dose\/d period, compared with the\nbaseline, 1 dose\/d, and follow-up periods.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Administration\nof either drug every 24 hours for short-term\ntreatment does not reduce IOP significantly.\nAdministering either drug every 12 hours induced a\nsignificant reduction of IOP; however, controlling for\nall variables, the reduction was less than 2 mm Hg.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2001;61:709\u2013713)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.709","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:28:14Z","timestamp":1133890094000},"page":"709-713","source":"Crossref","is-referenced-by-count":43,"title":["Effect of topical administration of 2% dorzlamide hydrochloride or 2% dorzlamide hydrochloride-0.5% timolol maleate on intraocular pressure in clinically normal horses"],"prefix":"10.2460","volume":"62","author":[{"given":"A. 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