{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:56:22Z","timestamp":1761512182567,"version":"3.38.0"},"reference-count":42,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To quantify geometric, inertial, and histomorphometric\nproperties at the mid-diaphyseal level\nof left and right metacarpal bones (MCB) of racing\nGreyhounds.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014MCB from 7 racing Greyhounds\neuthanatized for reasons unrelated to MCB\nabnormalities.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014Mid-diaphyseal transverse sections of\nleft and right MCB were stained with H&amp;E or microradiographed.\nImages of stained sections were digitized,\nand cross-sectional area, cortical area, and maximum\nand minimum area moments of inertia of each\nbone were determined. Histomorphometric data\n(osteonal density, osteonal birefringence, and\nendosteal new lamellar bone thickness) were collected\nin 4 quadrants (dorsal, palmar, lateral, medial).\nValues were compared between limbs and among\nbones and quadrants.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Cross-sectional area, cortical area, and\nmaximum and minimum moments of inertia of left\nMCB-IV and -V were significantly greater, compared\nwith contralateral bones. Overall osteonal densities in\nthe dorsal quadrants of left MCB were greater, compared\nwith lateral and medial quadrants. Also, percentage\nof birefringent osteons was significantly\ngreater in the dorsal quadrant of left MCB-III, -IV, and\n-V, compared with the palmar quadrant. Thickness of\nnew endosteal lamellar bone was not significantly\ninfluenced by limb, bone, or quadrant.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Increased\ncortical thickness and geometric properties of left\nMCB-IV and -V of Greyhounds, together with altered\nturnover and orientation of osteons in the dorsal\nquadrants of left MCB, are site-specific adaptive\nresponses associated with asymmetric cyclic loading\nas a result of racing on circular tracks. Site-specific\nadaptive remodeling may be important in the\netiopathogenesis of fatigue fractures in racing Greyhounds.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2001;62:787\u2013793)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.787","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:28:14Z","timestamp":1133890094000},"page":"787-793","source":"Crossref","is-referenced-by-count":20,"title":["Site-specific adaptive remodeling of Greyhound metacarpal cortical bone subjected to asymmetrical cyclic loading"],"prefix":"10.2460","volume":"62","author":[{"given":"Kenneth A.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerry 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