{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:57:49Z","timestamp":1761742669435,"version":"3.38.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To assess blood oxygen binding in calves\nwith diarrhea.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201422 dairy and 26 double-muscled calves\nwith diarrhea, 31 healthy dairy calves and 37 healthy\ndouble-muscled calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Severity of disease, including the ability\nof affected calves to stand, was evaluated. Hydration\nand signs of depression were scored. Venous and\narterial blood samples were collected, and 2,3-diphosphoglycerate,\nATP, chloride, inorganic phosphate, lactate,\npyruvate, total protein, albumin, and hemoglobin\nconcentrations, and Hct, pH, Pco<jats:sub>2<\/jats:sub>, and Po<jats:sub>2<\/jats:sub> were\ndetermined. Oxygen equilibrium curves (OEC) were\nconstructed under standard conditions, and oxygen\nextraction ratios were calculated.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Recumbent calves of both breed-types\nwere more dehydrated and had more severe signs of\ndepression than ambulatory affected calves. In both\nbreed-types, hemoglobin oxygen affinity was\nincreased in calves with diarrhea, compared with\nhealthy calves, as indicated by a decrease in standard\npartial oxygen pressure (P50). Diarrhea induced\nhypocapnia and hypothermia in the most severely\naffected calves, which counteracted the acidosisinduced\nright shift in arterial and venous OEC. Arterial\nand venous P50 were significantly less in doublemuscled\ncalves with diarrhea than healthy calves,\nwhereas P50 for affected dairy calves were similar to\nthose of healthy calves. Except in the most severely\naffected dairy calves, oxygen extraction ratio was significantly\nless in calves with diarrhea, compared with\nhealthy calves.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Release of\noxygen from blood may be impaired in calves with\ndiarrhea, depending on the effect of the disease on\ncertain blood biochemical variables. 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