{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:50:12Z","timestamp":1775742612916,"version":"3.50.1"},"reference-count":29,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate effects of topical application\nof a 2% solution of dorzolamide on intraocular pressure\n(IOP) and aqueous humor flow rate in clinically\nnormal dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201415 Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014The IOP was measured in both eyes of\nall dogs for 3 days to determine baseline values. In a\nsingle-dose study, 50 \u03bcl of dorzolamide or control\nsolution was applied in both eyes at 7:00 AM, and IOP\nwas measured 7 times\/d. In a multiple-dose study,\ndorzolamide or control solution was applied to both\neyes 3 times\/d for 6 days, and IOP was measured 4\ntimes\/d during treatment and for 5 days after cessation\nof treatment. Aqueous humor flow rate was measured\nfor all dogs fluorophotometrically prior to treatment\nand during the multiple-dose study.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In the single-dose study, dorzolamide significantly\ndecreased IOP from 30 minutes to 6 hours\nafter treatment. Mean decrease in IOP during this\ntime span was 3.1 mm Hg (18.2%). Maximal\ndecrease was detected 6 hours after treatment (3.8\nmm Hg, 22.5%). In the multiple-dose study, dorzolamide\ndecreased IOP at all time points, and maximal\ndecrease was detected 3 hours after treatment (4.1\nmm Hg, 24.3%). Mean aqueous humor flow rate\ndecreased from 5.9 to 3.4 \u03bcl\/min (43%) after treatment\nin the dorzolamide group.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Topical application\nof a 2% solution of dorzolamide significantly\ndecreases IOP and aqueous humor flow rate in clinically\nnormal dogs. Therefore, topical administration of\ndorzolamide should be considered for the medical\nmanagement of dogs with glaucoma. (<jats:italic>Am J Vet Res<\/jats:italic>\n2001;62:859\u2013863)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.859","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:31:35Z","timestamp":1133890295000},"page":"859-863","source":"Crossref","is-referenced-by-count":35,"title":["Effects of topical application of a 2% solution of dorzolamide on intraocular pressure and aqueous humor flow rate in clinically normal dogs"],"prefix":"10.2460","volume":"62","author":[{"given":"Margaret A.","family":"Cawrse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane V. H.","family":"Hendrix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_234","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0002-9394(54)92027-9","volume":"37","author":"Becker B","year":"1954","journal-title":"Diamox. Am J Ophthalmol"},{"key":"p_2_235","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archopht.1958.00940080445012","volume":"60","author":"Gonzales-Jiminez E","year":"1958","journal-title":"Arch Ophthalmol"},{"key":"p_3_236","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1001\/archopht.1959.04220040141020","volume":"62","author":"Drance SM","year":"1959","journal-title":"Arch Ophthalmol"},{"key":"p_4_237","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0002-9394(14)75247-X","volume":"85","author":"Lichter PR","year":"1978","journal-title":"Am J Ophthalmol"},{"key":"p_5_238","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1001\/archopht.1977.04450080088009","volume":"95","author":"Epstein DL","year":"1977","journal-title":"Arch Ophthalmol"},{"key":"p_6_239","first-page":"1563","volume":"11","author":"Wallace TR","year":"1979","journal-title":"Ann Ophthalmol"},{"key":"p_7_240","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0161-6420(88)33110-6","volume":"95","author":"Mogk LG","year":"1988","journal-title":"Ophthalmology"},{"key":"p_8_241","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1001\/archopht.1971.00990050003001","volume":"85","author":"Maren TH","year":"1971","journal-title":"Arch Ophthalmol"},{"key":"p_9_242","first-page":"334","volume":"40","author":"Gelatt KN","year":"1979","journal-title":"Am J Vet Res"},{"key":"p_10_243","first-page":"124","author":"Gum GG","year":"1991","journal-title":"Philadelphia: Lea & Febiger"},{"key":"p_11_244","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1001\/archopht.1992.01080160073033","volume":"110","author":"Lippa EA","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"p_12_245","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/archopht.1993.01090100051026","volume":"111","author":"Wilkerson M","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"p_13_246","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1442-9071.1996.tb01549.x","volume":"24","author":"Simpson AJ","year":"1996","journal-title":"Aust N Z J Ophthalmol"},{"key":"p_14_247","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1089\/jop.1999.15.305","volume":"15","author":"Le HH","year":"1999","journal-title":"J Ocul Pharmacol Ther"},{"key":"p_15_248","first-page":"92","volume":"38","author":"Yamazaki Y","year":"1994","journal-title":"Jpn J Ophthalmol"},{"key":"p_16_249","first-page":"1621","volume":"40","author":"Schmitz K","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"p_17_250","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1001\/archopht.1991.01080090123036","volume":"109","author":"Wang RF","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"p_18_251","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2460\/ajvr.1991.52.12.2067","volume":"52","author":"King TC","year":"1991","journal-title":"Am J Vet Res"},{"key":"p_19_252","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0014-4835(66)80009-X","volume":"5","author":"Jones RF","year":"1966","journal-title":"Exp Eye Res"},{"key":"p_20_253","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(78)90083-0"},{"key":"p_21_254","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archopht.1976.03910030211008","volume":"94","author":"Bloom JN","year":"1976","journal-title":"Arch Ophthalmol"},{"key":"p_22_255","first-page":"149","volume":"101","author":"Coakes RL","year":"1981","journal-title":"Trans Ophthalmol Soc U K"},{"key":"p_23_256","doi-asserted-by":"publisher","DOI":"10.1007\/BF00942929"},{"key":"p_24_257","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.2001.62.853"},{"key":"p_25_258","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2460\/ajvr.1996.57.01.79","volume":"57","author":"Miller PE","year":"1996","journal-title":"Am J Vet Res"},{"key":"p_26_259","first-page":"419","volume":"27","author":"Wistrand PJ","year":"1986","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"p_27_260","first-page":"51","author":"van Best JA","year":"1993","journal-title":"Portugal: Coimbra"},{"key":"p_28_261","first-page":"1473","volume":"73","author":"Peiffer","year":"1976","journal-title":"Am J Vet Res"},{"key":"p_29_262","first-page":"1","volume":"3","author":"Brubaker RF","year":"1992","journal-title":"Philadelphia: JB Lippincott Co"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/62\/6\/ajvr.2001.62.859.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/62\/6\/ajvr.2001.62.859.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/62\/6\/ajvr.2001.62.859.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:02:36Z","timestamp":1741348956000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/62\/6\/ajvr.2001.62.859.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":29,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2001.62.859","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}