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Sections were subjectively\nevaluated for location and intensity of staining.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Cartilage affected by OCD had a variety of\npathologic changes and significantly lower GAG concentrations\nthan did normal cartilage. Normal cartilage\nhad no detectable type-I collagen. For dogs &lt; 9\nmonths of age, cartilage affected by OCD had significantly\nmore type-I collagen but significantly less type-\nX collagen than did control cartilage. For dogs &gt; 12\nmonths of age, cartilage affected by OCD contained\nsignificantly more type-I collagen than did control cartilage.\nThere was a significant negative correlation\nbetween immunoreactivity of type-I collagen and that\nof type-II and -X collagen. A significant positive correlation\nwas found between immunoreactivity of type-II\nand -X collagen.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Cartilage\naffected by OCD contains less GAG, more type-I collagen,\nand less type-X collagen, compared with normal\ncartilage. A direct correlation between these\nchanges and the etiopathogenesis of OCD was not\nestablished. 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