{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:59:09Z","timestamp":1778691549291,"version":"3.51.4"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare the safety and efficacy of\npreoperative administration of meloxicam with that of\nketoprofen and butorphanol in dogs undergoing\nabdominal surgery.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201436 dogs undergoing laparotomy, splenectomy,\nor cystotomy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were randomly assigned to 1 of 3\ngroups. In the first part of the study, dogs were given\na single dose of meloxicam, ketoprofen, or a placebo,\nand buccal mucosal bleeding times were measured.\nIn the second part of the study, dogs were given\nmeloxicam, ketoprofen, or butorphanol prior to\nsurgery. Dogs in the butorphanol group received a\nsecond dose immediately after surgery. Pain scores\n(1 to 10) were assigned hourly for 20 hours after\nsurgery and used to determine an overall efficacy\nscore for each dog. Dogs with a pain score \u2265 3 were\ngiven oxymorphone for pain. Dogs were euthanatized\n8 days after surgery, and gross and histologic examinations\nof the liver, kidneys, and gastrointestinal tract\nwere conducted.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Overall efficacy was rated as good or excellent\nin 9 of the 12 dogs that received meloxicam,\ncompared with 9 of the 12 dogs that received ketoprofen\nand only 1 of the 12 dogs that received butorphanol.\nNo clinically important hematologic, biochemical,\nor pathologic abnormalities were detected.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggest\nthat preoperative administration of meloxicam is a\nsafe and effective method of controlling postoperative\npain for 20 hours in dogs undergoing abdominal\nsurgery; the analgesic effects of meloxicam were comparable\nto those of ketoprofen and superior to those of\nbutorphanol. 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