{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:07:06Z","timestamp":1790626026696,"version":"4.1.0"},"reference-count":73,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2001,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate calcium balance and parathyroid\ngland function in healthy horses and horses with\nenterocolitis and compare results of an immunochemiluminometric\nassay (ICMA) with those of an\nimmunoradiometric assay (IRMA) for determination of\nserum intact parathyroid hormone (PTH) concentrations\nin horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201464 horses with enterocolitis and 62 healthy\nhorses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014Blood and urine samples were collected\nfor determination of serum total calcium, ionized calcium\n(Ca<jats:sup>2+<\/jats:sup>) and magnesium (Mg<jats:sup>2+<\/jats:sup>), phosphorus, BUN,\ntotal protein, creatinine, albumin, and PTH concentrations,\nvenous blood gases, and fractional urinary clearance\nof calcium (FCa) and phosphorus (FP). Serum\nconcentrations of PTH were measured in 40 horses by\nuse of both the IRMA and ICMA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Most (48\/64; 75%) horses with enterocolitis\nhad decreased serum total calcium, Ca2+, and Mg2+\nconcentrations and increased phosphorus concentrations,\ncompared with healthy horses. Serum PTH concentration\nwas increased in most (36\/51; 70.6%) horses\nwith hypocalcemia. In addition, FCa was significantly\ndecreased and FP significantly increased in\nhorses with enterocolitis, compared with healthy horses.\nResults of ICMA were in agreement with results of\nIRMA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Enterocolitis\nin horses is often associated with hypocalcemia;\n79.7% of affected horses had ionized hypocalcemia.\nBecause FCa was low, it is unlikely that renal calcium\nloss was the cause of hypocalcemia. Serum PTH concentrations\nvaried in horses with enterocolitis and concomitant\nhypocalcemia. However, we believe low PTH\nconcentration in some hypocalcemic horses may be\nthe result of impaired parathyroid gland function. ( <jats:italic>Am\nJ Vet Res<\/jats:italic> 2001;62:938\u2013947)<\/jats:p>","DOI":"10.2460\/ajvr.2001.62.938","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:31:35Z","timestamp":1133890295000},"page":"938-947","source":"Crossref","is-referenced-by-count":82,"title":["Comparison of serum parathyroid hormone and ionized calcium and magnesium concentrations and fractional urinary clearance of calcium and phosphorus in healthy horses and horses with enterocolitis"],"prefix":"10.2460","volume":"62","author":[{"given":"Ramiro E.","family":"Toribio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine W.","family":"Kohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis J.","family":"Chew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Sams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Rosol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_668","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0195-5616(96)50060-4","volume":"26","author":"Rosol TJ","year":"1996","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"p_2_669","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/ajplegacy.1973.224.5.1143","volume":"224","author":"Agus ZS","year":"1973","journal-title":"Am J Physiol"},{"key":"p_3_670","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/10409239609110575","volume":"31","author":"Hurwitz S","year":"1996","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"p_4_671","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1210\/endo-118-2-824","volume":"118","author":"McSheehy PM","year":"1986","journal-title":"Endocrinology"},{"key":"p_5_672","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1210\/endo-119-3-1406","volume":"119","author":"Nemere I","year":"1986","journal-title":"Endocrinology"},{"key":"p_6_673","doi-asserted-by":"crossref","first-page":"36","DOI":"10.7326\/0003-4819-107-1-36","volume":"107","author":"Zaloga GP","year":"1987","journal-title":"Ann Intern Med"},{"key":"p_7_674","first-page":"143","volume":"24","author":"Zaloga GP","year":"1988","journal-title":"Circ Shock"},{"key":"p_8_675","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1055\/s-2007-978842","volume":"30","author":"Nakamura T","year":"1998","journal-title":"Horm Metab Res"},{"key":"p_9_676","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200012000-00024"},{"key":"p_10_677","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/00005373-197709000-00004","volume":"17","author":"Sibbald WJ","year":"1977","journal-title":"J Trauma"},{"key":"p_11_678","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1939-1676.1996.tb02087.x","volume":"10","author":"Grubb TL","year":"1996","journal-title":"J Vet Intern Med"},{"key":"p_12_679","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/endo-119-5-1954","volume":"119","author":"Kinoshita Y","year":"1986","journal-title":"Endocrinology"},{"key":"p_13_680","first-page":"1407","author":"Strewler GJ","year":"1995","journal-title":"Inc"},{"key":"p_14_681","doi-asserted-by":"crossref","unstructured":"Rosol TJ, Capen CC. Calcium-regulating hormones and diseases of abnormal mineral (calcium, phosphorus, magnesium) metabolism. In: Kaneko JJ, Harvey JW, Bruss ML, eds. Clinical biochemistry of domestic animals. 5th ed. San Diego: Academic Press, 1997;619-702.","DOI":"10.1016\/B978-012396305-5\/50024-5"},{"key":"p_15_682","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1210\/jcem-73-5-1067","volume":"73","author":"Fatemi S","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"p_16_683","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1210\/jcem-61-5-933","volume":"61","author":"Rude RK","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"p_17_684","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/ki.1993.111","volume":"43","author":"Felsenfeld AJ","year":"1993","journal-title":"Kidney Int"},{"key":"p_18_685","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/ki.1991.315","volume":"40","author":"Rodriguez M","year":"1991","journal-title":"Kidney Int"},{"key":"p_19_686","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1210\/jcem-65-3-407","volume":"65","author":"Brown RC","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"p_20_687","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/clinchem\/33.8.1364","volume":"33","author":"Nussbaum SR","year":"1987","journal-title":"Clin Chem"},{"key":"p_21_688","first-page":"1123","volume":"50","author":"Torrance AG","year":"1989","journal-title":"Am J Vet Res"},{"key":"p_22_689","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1748-5827.1993.tb02594.x","volume":"34","author":"Barber PJ","year":"1993","journal-title":"J Small Anim Pract"},{"key":"p_23_690","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.59.71"},{"key":"p_24_691","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2527\/1996.744834x","volume":"74","author":"Martin KL","year":"1996","journal-title":"J Anim Sci"},{"key":"p_25_692","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/j.1939-1676.1997.tb00480.x","volume":"11","author":"Beyer MJ","year":"1997","journal-title":"J Vet Intern Med"},{"key":"p_26_693","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.2042-3306.1998.tb04522.x","volume":"30","author":"Estepa JC","year":"1998","journal-title":"Equine Vet J"},{"key":"p_27_694","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.2460\/ajvr.1998.59.12.1605","volume":"59","author":"Aguilera-Tejero E","year":"1998","journal-title":"Am J Vet Res"},{"key":"p_28_695","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2460\/javma.1998.212.01.84","volume":"212","author":"Frank N","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"p_29_696","first-page":"586","volume":"48","author":"Roussel AJ","year":"1987","journal-title":"Am J Vet Res"},{"key":"p_30_697","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2460\/javma.1998.212.12.1915","volume":"212","author":"Peauroi JR","year":"1998","journal-title":"J Am Vet Med Assoc"},{"key":"p_31_698","first-page":"134","volume":"63","author":"Ronen N","year":"1992","journal-title":"J S Afr Vet Assoc"},{"key":"p_32_699","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1136\/vr.138.23.568","volume":"138","author":"Clarke CJ","year":"1996","journal-title":"Vet Rec"},{"key":"p_33_700","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.2042-3306.1989.tb02152.x","volume":"21","author":"Marr CM","year":"1989","journal-title":"Equine Vet J"},{"key":"p_34_701","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1939-1676.1998.tb00496.x","volume":"12","author":"Couetil LL","year":"1998","journal-title":"J Vet Intern Med"},{"key":"p_35_702","first-page":"1358","volume":"182","author":"Harrington DD","year":"1983","journal-title":"J Am Vet Med Assoc"},{"key":"p_36_703","first-page":"317","volume":"76","author":"Elfers RS","year":"1986","journal-title":"Cornell Vet"},{"key":"p_37_704","first-page":"197","volume":"95","author":"Chen CK","year":"1996","journal-title":"J Formos Med Assoc"},{"key":"p_38_705","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/000456329703400115","volume":"34","author":"Michelangeli VP","year":"1997","journal-title":"Ann Clin Biochem"},{"key":"p_39_706","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1939-1676.1993.tb01014.x","volume":"7","author":"Roussel AJ","year":"1993","journal-title":"J Vet Intern Med"},{"key":"p_40_707","first-page":"83","volume":"14","author":"Babson AL","year":"1991","journal-title":"J Clin Immunoassay"},{"key":"p_41_708","first-page":"304","author":"Fisher LD","year":"1993","journal-title":"New York: John Wiley & Sons Inc"},{"key":"p_42_709","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.2460\/ajvr.1990.51.08.1206","volume":"51","author":"Kohn CW","year":"1990","journal-title":"Am J Vet Res"},{"key":"p_43_710","first-page":"323","author":"Glantz SA","year":"1997","journal-title":"New York:McGraw-Hill Book Co"},{"key":"p_44_711","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","volume":"1","author":"Bland JM","year":"1986","journal-title":"Lancet"},{"key":"p_45_712","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90277-N"},{"key":"p_46_713","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/clinids\/12.5.736","volume":"12","author":"Sperber SJ","year":"1990","journal-title":"Rev Infect Dis"},{"key":"p_47_714","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1605"},{"key":"p_48_715","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00418-5"},{"key":"p_49_716","first-page":"429","volume":"21","author":"Taylor B","year":"1978","journal-title":"Can J Surg"},{"key":"p_50_717","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/00003246-197803000-00047","volume":"6","author":"Sibbald WJ","year":"1978","journal-title":"Crit Care Med"},{"key":"p_51_718","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2143(99)90053-7"},{"key":"p_52_719","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1172\/JCI106476","volume":"50","author":"Arnaud CD","year":"1971","journal-title":"J Clin Invest"},{"key":"p_53_720","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70161-6"},{"key":"p_54_721","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7207"},{"key":"p_55_722","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.2460\/ajvr.1990.51.08.1221","volume":"51","author":"Seethanathan P","year":"1990","journal-title":"Am J Vet Res"},{"key":"p_56_723","doi-asserted-by":"crossref","first-page":"792","DOI":"10.2460\/ajvr.1998.59.06.792","volume":"59","author":"Barton MH","year":"1998","journal-title":"Am J Vet Res"},{"key":"p_57_724","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2460\/ajvr.1999.60.08.969","volume":"60","author":"Bueno AC","year":"1999","journal-title":"Am J Vet Res"},{"key":"p_58_725","doi-asserted-by":"publisher","DOI":"10.1210\/en.136.2.788"},{"key":"p_59_726","first-page":"58","volume":"4","author":"Hotchkiss RS","year":"1996","journal-title":"New Horiz"},{"key":"p_60_727","first-page":"72","volume":"4","author":"Sayeed MM","year":"1996","journal-title":"New Horiz"},{"key":"p_61_728","doi-asserted-by":"crossref","unstructured":"Dinarello CA. Interleukin-1. Rev Infect Dis 1984;6:51-95.","DOI":"10.1093\/clinids\/6.1.51"},{"key":"p_62_729","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0272-6386(12)80727-X","volume":"21","author":"Massry SG","year":"1993","journal-title":"Am J Kidney Dis"},{"key":"p_63_730","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1073\/pnas.90.9.3933","volume":"90","author":"Song SK","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"p_64_731","first-page":"173","volume":"29","author":"Breidenbach A","year":"1998","journal-title":"Vet Res"},{"key":"p_65_732","first-page":"210","volume":"19","author":"Kayne LH","year":"1993","journal-title":"Miner Electrolyte Metab"},{"key":"p_66_733","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199501000-00019"},{"key":"p_67_734","first-page":"314","volume":"19","author":"Abbott LG","year":"1993","journal-title":"Miner Electrolyte Metab"},{"key":"p_68_735","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jbmr.5650110714","volume":"11","author":"Almaden Y","year":"1996","journal-title":"J Bone Miner Res"},{"key":"p_69_736","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0272-6386(97)90086-X","volume":"30","author":"Kates DM","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"p_70_737","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/000456329603300618","volume":"33","author":"Stockl D","year":"1996","journal-title":"Ann Clin Biochem"},{"key":"p_71_738","first-page":"155","volume":"61","author":"Van Heerden J","year":"1990","journal-title":"J S Afr Vet Assoc"},{"key":"p_72_739","first-page":"491","volume":"103","author":"Enbergs H","year":"1996","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"p_73_740","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90806-7"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/62\/6\/ajvr.2001.62.938.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/62\/6\/ajvr.2001.62.938.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/62\/6\/ajvr.2001.62.938.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:02:38Z","timestamp":1741348958000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/62\/6\/ajvr.2001.62.938.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6,1]]},"references-count":73,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2001.62.938","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6,1]]}}}