{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:20:52Z","timestamp":1762100452685,"version":"3.38.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effect of experimental\nintraluminal distention on microvascular perfusion of\nthe small colon in horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20146 mixed-breed healthy horses (mean age\n[\u00b1 SD], 9.1 \u00b1 2 years).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Under general anesthesia, the small\ncolon was exposed by celiotomy and 3 segments\nwere demarcated. In 1 of these segments, intraluminal\nobstruction was created by placement of a latex\nballoon inflated to a pressure of 40 mm Hg (obstructed\nsegment). The other segments were the sham-operated\nsegment and the control segment.\nMicrovascular perfusion was evaluated in the mucosal,\nsubmucosal, muscular, and serosal layers by injection\nof 15-\u00b5m-diameter colored microspheres into\nbranches of the caudal mesenteric artery. Recovery of\nmicrospheres was performed by tissue digestion,\nwashing, and centrifugation. Distribution of microspheres\nin the intestinal layers was evaluated by direct\nobservation of stained frozen sections by light\nmicroscopy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014A significant reduction was observed in\ntotal microvascular perfusion of obstructed segments,\nwhich was 26.4% of that of control segments.\nThis reduction was not evident in the mucosal\nlayer.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Intraluminal distention\nof the equine small colon wall can promote\nischemia by a reduction in microvascular perfusion in the\nintestinal wall. Intestinal layers do not seem to be affected\nto the same extent, because the absolute value for\nmucosal perfusion did not decrease in the obstructed\nsegment. 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