{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:30:19Z","timestamp":1761561019997,"version":"3.38.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine plasma concentrations of\nadrenocorticotrophic hormone (ACTH) and\n\u03b1-melanocyte stimulating-hormone (\u03b1-MSH) in\nhealthyferrets and ferrets with hyperadrenocorticism.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201416 healthy, neutered, privately owned ferrets,\n28 healthy laboratory ferrets (21 sexually intact\nand 7 neutered), and 28 ferrets with hyperadrenocorticism.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014Healthy ferrets were used for determination\nof reference plasma concentrations of ACTH\nand \u03b1-MSH. Diagnosis of hyperadrenocorticism was\nmade on the basis of history, clinical signs, urinary\ncorticoid-to-creatinine ratios, ultrasonography of the\nadrenal glands, and macroscopic or microscopic evaluation\nof the adrenal glands. Blood samples were collected\nduring isoflurane anesthesia. Plasma concentrations\nof ACTH and \u03b1-MSH were measured by\nradioimmunoassay.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Plasma concentrations of ACTH in 23\nhealthy neutered ferrets during the breeding season\nranged from 4 to 145 ng\/L (median, 50 ng\/L).\nPlasma concentrations of \u03b1-MSH in 44 healthy\nneutered or sexually intact ferrets during the breeding\nseason ranged from &lt; 5 to 617 ng\/L (median, 37\nng\/L). Reference values (the central 95% of the values)\nfor ACTH and \u03b1-MSH were 13 to 100 ng\/L and\n8 to 180 ng\/L, respectively. Plasma concentrations\nof ACTH and \u03b1-MSH in ferrets with hyperadrenocorticism\nranged from 1 to 265 ng\/L (median, 45\nng\/L) and 10 to 148 ng\/L (median, 46 ng\/L), respectively.\nThese values were not significantly different\nfrom those of healthy ferrets. Plasma ACTH concentrations\nof sexually intact female ferrets in\nestrus were significantly higher than those of\nneutered females.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Ferrets\nwith hyperadrenocorticism did not have\ndetectable abnormalities in plasma concentrations\nof ACTH or \u03b1-MSH. The findings suggest\nthat hyperadrenocorticism in ferrets is an ACTH\nand \u03b1-MSH-independent condition.\u2014(<jats:italic>Am J Vet\nRes<\/jats:italic> 2002;63:1395\u20131399)<\/jats:p>","DOI":"10.2460\/ajvr.2002.63.1395","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T14:43:47Z","timestamp":1135176227000},"page":"1395-1399","source":"Crossref","is-referenced-by-count":18,"title":["Plasma concentrations of adrenocorticotrophic hormone and \u03b1-melanocyte-stimulating hormone in ferrets (Mustela putorius furo) with hyperadrenocorticism"],"prefix":"10.2460","volume":"63","author":[{"given":"Nico J.","family":"Schoemaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Mol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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