{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:06:03Z","timestamp":1771466763535,"version":"3.50.1"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of feeding aspirin and\nsupplemental vitamin E on growth performance, lung\nlesions, plasma concentrations of 3-methylindole (3MI),\nand 3-methyleneindolenine (3MEIN)-adduct concentrations\nin blood and pulmonary tissues of feedlot cattle.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014256 crossbred steers; 64 cattle were used in\nexperiment 1 and 192 cattle were used in experiment 2.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedures<\/jats:bold>\u2014A 2 \u00d7 2 factorial design was used for\neach experiment. Treatment factors were aspirin (0 or\n3 g daily) and vitamin E (200 or 1,500 IU daily). Steers\nwere housed in pens (8 steers\/pen). Steers were\nslaughtered on days 59 and 138 for experiments 1\nand 2, respectively. Lungs were grossly evaluated.\nPlasma 3MI concentration was determined, and\n3MEIN-adduct concentrations were measured in\nblood and pulmonary tissues.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Treatment was not associated with\nimprovement or adverse effects on weight gain, drymatter\nintake, or feed efficiency in experiment 2. In\nexperiment 1, 36 of 63 (57.1%) steers had lung\nlesions. Lesions were not associated with treatment\nor concentrations of 3MI and 3MEIN-adduct. Plasma\n3MI concentration and concentrations of 3MEINadduct\nin blood and pulmonary tissues were\n3.11 \u00b5g\/mL, 0.51 U\/\u00b5g of protein, and 0.49 U\/\u00b5g of\nprotein, respectively. Aspirin was associated with\nincreased blood concentrations of 3MEIN-adduct for\ndiets that did not contain supplemental vitamin E.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Differences in\nperformance of feedlot steers were not associated with\ntreatment diet. It is possible that concurrent exposure of\nfeedlot cattle to other factors typically associated with\ndevelopment of respiratory tract disease would affect\nthese findings. 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