{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:32:37Z","timestamp":1778279557234,"version":"3.51.4"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate primary hemostasis following\nadministration of desmopressin acetate (DDAVP) to\nDoberman Pinschers with type-1 von Willebrand disease\n(vWD).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201416 nonanemic Doberman Pinschers with\ntype-1 vWD.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Closure time (CT), defined as time\nrequired for occlusion of an aperture by a platelet plug\nassessed within the point-of-care instrument, plasma\nvon Willebrand factor (vWF) concentration, and buccal\nmucosal bleeding time (BMBT) were determined\nbefore and 1 hour after administration of DDAVP (1\n\u00b5g\/kg, SC).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Baseline closure times measured with\nadenosine diphosphate ([ADP-CT], 108 to &gt; 300 seconds;\nreference range, 52 to 86 seconds) and epinephrine\n([EPI-CT], 285 to &gt; 300 seconds; 97 to 225\nseconds) as platelet agonists were prolonged in all\ndogs. Following DDAVP administration, ADP-CT (59 to\n186 seconds) was significantly shortened from baseline,\nbut there was no decrease in EPI-CT. Although\nmean plasma vWF concentration increased significantly\nafter DDAVP administration, only 1 dog had an\nincrease of &gt; 35 U\/dL. There was no correlation\nbetween increase in plasma vWF concentration and\nshortening of the ADP-CT. Baseline BMBT was prolonged\nin 12 of 14 dogs, with significant shortening of\nBMBT after DDAVP administration in 6 of 7 dogs. In\nvitro replacement of vWF-deficient plasma with plasma\nfrom an unaffected dog shortened the ADP-CT,\nwhereas in vitro addition of DDAVP had no effect.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Administration\nof DDAVP to Doberman Pinschers with type-1 vWD\nresulted in improved hemostatic function, as assessed\nby the point-of-care instrument and shortening of\nBMBT, despite minimal increase in plasma vWF concentration.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2002;63:1700\u20131706)<\/jats:p>","DOI":"10.2460\/ajvr.2002.63.1700","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:27:26Z","timestamp":1138040846000},"page":"1700-1706","source":"Crossref","is-referenced-by-count":27,"title":["Effect of desmopressin acetate administration on primary hemostasis in Doberman Pinschers with type-1 von Willebrand disease as assessed by a point-of-care 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