{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:10:49Z","timestamp":1741353049505,"version":"3.38.0"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of long-term treatment\nwith tetracycline and niacinamide on antibody\nproduction in dogs by measuring postvaccinal serum\nconcentrations of antibodies against canine parvovirus\nand canine distemper virus.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201410 dogs receiving long-term treatment\nwith tetracycline and niacinamide (treatment group)\nand 10 healthy dogs (control group).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014The treatment group included 9 dogs\nwith discoid lupus erythematosus and 1 dog with\npemphigus foliaceus on long-term treatment (&gt; 12\nmonths) with tetracycline and niacinamide. The control\ngroup included 10 healthy dogs with no clinical\nsigns of disease and no administered medications for\nthe past 3 months. Blood samples were obtained\nfrom all dogs by jugular venipuncture. Serum antibody\ntiters against canine parvovirus and canine distemper\nvirus antigens were measured, using hemaglutination\ninhibition and serum neutralization, respectively, and\ncompared between groups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014A significant difference in antibody titers\nbetween treatment- and control-group dogs was not\nfound. All dogs had protective antibody titers against\ncanine distemper virus, and 8 of 10 dogs from each\ngroup had protective titers against canine parvovirus\ninfection.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014These results\nprovide evidence that long-term treatment with tetracycline\nand niacinamide does not interfere with routine\nvaccinations and thus does not seem to influence\nantibody production in dogs. 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