{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:54:19Z","timestamp":1791266059618,"version":"4.1.0"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the efficacy of trilostane, a\n3\u03b2-hydroxysteroid dehydrogenase inhibitor, in dogs\nwith pituitary-dependent hyperadrenocorticism (PDH).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201411 dogs with PDH.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014The initial dose of trilostane was 30 mg,\nPO, q 24 h for dogs that weighed &lt; 5 kg and 60 mg,\nPO, q 24 h for dogs that weighed \u2265 5 kg. A CBC\ncount, serum biochemical analyses, urinalysis, ACTH\nstimulation test, and ultrasonographic evaluation of\nthe adrenal glands were performed in each dog 1, 3\nto 4, 6 to 7, 12 to 16, and 24 to 28 weeks after initiation\nof treatment.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014All dogs responded well to treatment. All had\nreductions in polyuria-polydipsia and panting and an\nincrease in activity. Polyphagia decreased in 9 of 10\ndogs, and 9 of 11 dogs had improvement of coat quality\nand skin condition. Concentration of cortisol after\nACTH stimulation significantly decreased by 1 week\nafter initiation of treatment. After treatment for 6\nmonths, clinical signs resolved in 9 dogs. In the other 2\ndogs, marked clinical improvement was reported for 1\ndog, and moderate improvement was reported in the\nother dog. Ultrasonographically, there was a considerable\nchange in the parenchyma and an increase in size\nof the adrenal glands. Adverse effects consisted of 1\ndog with transient lethargy and 1 dog with anorexia.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Trilostane is\nan efficacious and safe medication for treatment of\ndogs with PDH. Additional studies in a larger group of\ndogs and characterization of progressive changes in\nadrenal glands are needed. (<jats:italic>Am J Vet Res<\/jats:italic> 2002;63:506\u2013512).<\/jats:p>","DOI":"10.2460\/ajvr.2002.63.506","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T14:49:01Z","timestamp":1135176541000},"page":"506-512","source":"Crossref","is-referenced-by-count":92,"title":["Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane"],"prefix":"10.2460","volume":"63","author":[{"given":"Nadja S.","family":"Ruckstuhl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Nett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Reusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"p_1_180","first-page":"242","author":"Feldman EC","year":"1989","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_2_181","first-page":"127","volume":"9","author":"Peterson ME","year":"1994","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"p_3_182","first-page":"1565","author":"Feldman EC.","year":"1995","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_4_183","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/vr.122.8.178","volume":"122","author":"Rijnberk A","year":"1988","journal-title":"Vet Rec"},{"key":"p_5_184","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1939-1676.1991.tb00945.x","volume":"5","author":"Kintzer PP","year":"1991","journal-title":"J Vet Intern Med"},{"key":"p_6_185","first-page":"242","author":"Feldman EC","year":"1996","journal-title":"Philadelphia: WB Saunders Co"},{"key":"p_7_186","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/joe.0.1010311","volume":"101","author":"Stolp R","year":"1984","journal-title":"J Endocrinol"},{"key":"p_8_187","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000414817","volume":"17","author":"Peterson ME","year":"1987","journal-title":"Frontiers Horm Res"},{"key":"p_9_188","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1677\/joe.0.1180271","volume":"118","author":"Rijnberk A","year":"1988","journal-title":"J Endocrinol"},{"key":"p_10_189","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2460\/javma.1990.197.01.71","volume":"197","author":"Feldman EC","year":"1990","journal-title":"J Am Vet Med Assoc"},{"key":"p_11_190","doi-asserted-by":"publisher","DOI":"10.1892\/0891-6640(1999)013<0291:TEOLDI>2.3.CO;2"},{"key":"p_12_191","doi-asserted-by":"publisher","DOI":"10.1016\/0039-128X(78)90010-7"},{"key":"p_13_192","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1210\/jcem-47-5-1042","volume":"47","author":"Komanicky P","year":"1978","journal-title":"J Clin Endocrinol Metab"},{"key":"p_14_193","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1530\/acta.0.1130104","volume":"113","author":"Nomura K","year":"1986","journal-title":"Acta Endocrinol"},{"key":"p_15_194","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2265.1983.tb00590.x","volume":"18","author":"Dewis P","year":"1983","journal-title":"Clin Endocinol"},{"key":"p_16_195","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1530\/acta.0.1020107","volume":"102","author":"Semple CG","year":"1983","journal-title":"Acta Endocrinol"},{"key":"p_17_196","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1939-1676.1996.tb02041.x","volume":"10","author":"Grooters AM","year":"1996","journal-title":"J Vet Intern Med"},{"key":"p_18_197","first-page":"239","volume":"141","author":"Hoerauf A","year":"1999","journal-title":"Schweiz Archiv Tierheilkd"},{"key":"p_19_198","first-page":"351","volume":"40","author":"Hoerauf A","year":"1995","journal-title":"Kleintierpraxis"},{"key":"p_20_199","first-page":"31","author":"Neiger R","year":"2000","journal-title":"Eur Soc Vet Intern Med Congr"},{"key":"p_21_200","first-page":"102","volume":"19","author":"Reusch C","year":"1991","journal-title":"Tierarztl Prax"},{"key":"p_22_201","first-page":"1534","volume":"46","author":"Nelson RW","year":"1985","journal-title":"Am J Vet Res"},{"key":"p_23_202","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(84)90134-5"},{"key":"p_24_203","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(85)90548-5"},{"key":"p_25_204","first-page":"334","author":"Aron DC","year":"2001","journal-title":"New York: McGraw-Hill Book Co"},{"key":"p_26_205","first-page":"279","volume":"141","author":"Keiser M","year":"1999","journal-title":"Schweiz Archiv Tierheilkd"}],"container-title":["American Journal of Veterinary Research"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/63\/4\/ajvr.2002.63.506.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/63\/4\/ajvr.2002.63.506.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/ajvr\/63\/4\/ajvr.2002.63.506.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:04:01Z","timestamp":1741349041000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/63\/4\/ajvr.2002.63.506.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.2460\/ajvr.2002.63.506","relation":{},"ISSN":["0002-9645"],"issn-type":[{"value":"0002-9645","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4,1]]}}}