{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:31:46Z","timestamp":1778279506451,"version":"3.51.4"},"reference-count":52,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To investigate effects of IV administered\ncarprofen on indices of renal function and results of\nserum biochemical and hematologic analyses in dogs\nanesthetized with acepromazine-thiopentone-isoflurane\nthat had low blood pressure during anesthesia.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20146 healthy Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014A randomized crossover study was conducted,\nusing the following treatments: saline (0.9%\nNaCl solution)-saline, saline-carprofen, and carprofensaline.\nSaline (0.08 ml\/kg) and carprofen (4 mg\/kg) were\nadministered IV. The first treatment was administered\n30 minutes before induction of anesthesia and immediately\nbefore administration of acepromazine (0.1\nmg\/kg, IM). Anesthesia was induced with thiopentone\n(25 mg\/ml, IV) and maintained with inspired isoflurane\n(2% in oxygen). The second treatment was administered\n30 minutes after onset of inhalation anesthesia.\nBlood gases, circulation, and ventilation were monitored.\nRenal function was assessed by glomerular filtration\nrate (GFR), using scintigraphy, serum biochemical\nanalyses, and urinalysis. Hematologic analysis was\nperformed. Statistical analysis was conducted, using\nANOVA or Friedman ANOVA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Values did not differ significantly among the\n3 treatments. For all treatments, sedation and anesthesia\ncaused changes in results of serum biochemical\nand hematologic analyses, a decrease in mean\narterial blood pressure to 65 mm Hg, an increase of\n115 pmol\/L in angiotensin II concentration, and an\nincrease of 100 seconds in time required to reach\nmaximum activity counts during scintigraphy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Carprofen\nadministered IV before or during anesthesia did not\ncause detectable significant adverse effects on renal\nfunction or results of serum biochemical and hematologic\nanalyses in healthy Beagles with low blood pressure\nduring anesthesia. 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