{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:59Z","timestamp":1775768999024,"version":"3.50.1"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objectives<\/jats:bold>\n                    \u2014To evaluate computed tomography (CT)\ndensitometry as a technique for quantifying contrast\nenhancement of compressive soft tissues in the\ncanine lumbosacral vertebral canal and to determine\nwhether the degree of contrast enhancement can be\nused to help predict tissue type or histopathologic characteristics.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201429 large breed dogs with lumbosacral\nstenosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Contrast-enhanced CT of L5-S3 was performed\nby use of a previously described protocol. At\neach disk level, CT densities of a water-filled syringe,\nepaxial muscles, and 4 vertebral canal locations were\nmeasured. Mean tissue enhancement was calculated\nby vertebral canal location, using water-filled syringe\nenhancement as a correction factor. Corrected CT\nenhancement was compared with tissue type,\ndegree of tissue inflammation, and degree of tissue\nactivity.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Intravenous contrast administration of contrast\nmedium significantly increased CT densities of\nwater-filled syringes and epaxial muscles. Corrected CT\nenhancement of vertebral canal soft tissues at stenotic\nsites was greater than at nonstenotic sites. There was\nno association between enhancement and tissue type\nfor any vertebral canal location. There was no correlation\nbetween enhancement and degree of tissue inflammation.\nThere was a correlation between enhancement\nand tissue activity in the dorsal vertebral canal only.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014A water-filled\nsyringe is a useful calibration tool for CT density measurements.\nThe degree of tissue contrast enhancement,\nmeasured by CT densitometry, can be helpful for\npredicting the location of compressive soft tissues in\ndogs with lumbosacral stenosis. However, it is of limited\nvalue for predicting compressive soft-tissue types or\nhistopathologic characteristics. 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