{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T19:42:06Z","timestamp":1760384526359,"version":"3.38.0"},"reference-count":12,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine tissue solubilities of desflurane,\nsevoflurane, enflurane, and halothane in swine\nand to evaluate the effects of freezing specimens on\ntissue solubility.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014Arterial blood samples and\nspecimens of brain, heart, liver, kidney, muscle, and\nsubcutaneous fat from 5 healthy female adult\nChinese Meishan pigs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Each tissue specimen was divided into 2\nparts. One part was used to measure tissue-gas partition\ncoefficients immediately after collection. The\nother part was frozen at \u201320 C for 6 days prior to\ndetermination of tissue-gas partition coefficients.\nTissue-gas and blood-gas partition coefficients were\nmeasured by use of gas chromatography, and tissueblood\npartition coefficients were calculated.\nRegression analysis was performed to determine\nwhether fat-gas partition coefficients were correlated\nwith lean tissue-gas partition coefficients.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Tissue-gas and blood-gas partition coefficients\nof halothane were greater than those of enflurane\nfollowed by coefficients of sevoflurane and desflurane.\nHowever, the order of anesthetic agents with\nthe greatest to smallest tissue-blood partition coefficients\nwas sevoflurane, halothane, enflurane, and\ndesflurane. Muscle-gas partition coefficients of\nsevoflurane and enflurane, liver-gas partition coefficients\nof desflurane and halothane, and the kidneygas\npartition coefficient of enflurane were significantly\ngreater in frozen specimens, compared with fresh\nspecimens. Lean tissue-gas partition coefficients of\nall 4 volatile anesthetics correlated directly with fatgas\npartition coefficients.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014The fat content\nof lean tissue is an important factor in determining\nthe tissue solubility of volatile anesthetics.\nFreezing specimens before determination of tissuegas\npartition coefficients may result in a false increase\nin tissue solubility. (<jats:italic>Am J Vet Res<\/jats:italic> 2002;63:74\u201377)<\/jats:p>","DOI":"10.2460\/ajvr.2002.63.74","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T17:35:51Z","timestamp":1133890551000},"page":"74-77","source":"Crossref","is-referenced-by-count":3,"title":["Tissue solubility of four volatile anesthetics in fresh and frozen tissue specimens from swine"],"prefix":"10.2460","volume":"63","author":[{"given":"Jian-Xin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"p_1_317","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1213\/00000539-199108000-00016","volume":"73","author":"Laster MJ","year":"1991","journal-title":"Anesth Analg"},{"key":"p_2_318","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1213\/00000539-199010000-00004","volume":"71","author":"Yasuda N","year":"1990","journal-title":"Anesth Analg"},{"key":"p_3_319","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-200107000-00047"},{"key":"p_4_320","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/00000542-196205000-00009","volume":"23","author":"Larson","year":"1962","journal-title":"Anesthesiology"},{"key":"p_5_321","first-page":"194","author":"Lowe HJ","year":"1968","journal-title":"New York: Grune & Stratton"},{"key":"p_6_322","first-page":"86","author":"Lowe HJ","year":"1969","journal-title":"Ciba Foundation Symposium. 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