{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:35:43Z","timestamp":1773239743186,"version":"3.50.1"},"reference-count":44,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the effect of pH with or\nwithout pepsin or taurocholic acid on the bioelectric\nproperties of gastric squamous mucosa in horses.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Sample Population<\/jats:bold>\u2014Gastric tissues obtained from\n16 adult horses that did not have evidence of gastric\ndisease.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Bioelectric properties of squamous\nmucosa were determined, using modified Ussing\nchambers. Tissues then were exposed to mucosal\npepsin (1 mg\/ml) or taurocholic acid (2.5 m<jats:italic>M<\/jats:italic>) under\nneutral (pH 7.4) or acidic (pH 1.7) conditions.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Exposure of mucosal sheets to an acidic pH\nresulted in an immediate and sustained decrease in\ntransmembrane potential difference and calculated\ntissue resistance. Pepsin or taurocholic acid did not\nsignificantly affect bioelectric variables when added to\na mucosal bath solution of pH 7.4. A synergistic effect\nbetween pepsin or taurocholic acid and mucosal acidification\nwas not detected.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Mucosal acidification\nwith or without pepsin or taurocholic acid\nresulted in reduced tissue resistance. These data support\nthe contention that squamous erosions or ulcers\nin horses are mediated, in part, by prolonged exposure\nof gastric squamous mucosa to luminal acid.\n(<jats:italic>Am J Vet Res<\/jats:italic> 2002;63:744\u2013749).<\/jats:p>","DOI":"10.2460\/ajvr.2002.63.744","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T14:49:15Z","timestamp":1135176555000},"page":"744-749","source":"Crossref","is-referenced-by-count":32,"title":["Effect of hydrochloric acid, pepsin, or taurocholate on bioelectric properties of gastric squamous mucosa in horses"],"prefix":"10.2460","volume":"63","author":[{"given":"Tamara Vetro","family":"Widenhouse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy D.","family":"Lester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred 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