{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:21:24Z","timestamp":1770218484798,"version":"3.49.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine effects of selegiline\nhydrochloride, phenylpropanolamine (PPA), or a combination\nof both on physiologic and behavioral variables\nin dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201440 adult hound-type dogs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Dogs were assigned to 4 groups. One\ngroup received selegiline (1 mg\/kg, PO, q 24 h) and\nPPA (1.1 mg\/kg, PO, q 8 h), a second group received\nselegiline alone, a third group received PPA alone, and\na fourth group received neither drug. Dogs were\nobserved 3 times\/d throughout the 30-day study (daily\nduring the first week, on alternate days during the\nnext 2 weeks, and again daily during the final week).\nObservers recorded rectal temperature, pulse, respiratory\nrate, oscillometric blood pressure, and lead-II\nECG and assessed 4 behaviors, using an analogue\nscale. Variables were compared among treatment\ngroups by use of a 2-factor ANOVA with data categorized\ninto three 10-day treatment periods. A similar\ncomparison was made among treatment groups with\ndata categorized by time of observation (morning,\nafternoon, or evening) for all study days.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Variables did not differ among groups at\nstudy initiation. Pulse rate was the only variable that\ndiffered significantly among treatment groups during\nthe study. During the first 10 days of treatment, dogs\nreceiving PPA had a lower pulse rate than dogs that\ndid not. Although signs of illness were apparent in a\nfew dogs, illness did not appear to be related to treatment.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Adverse\neffects were not detected after administration of\nselegiline, PPA, or a combination of the drugs in\nhealthy dogs. 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