{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:50Z","timestamp":1791281810466,"version":"4.1.0"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether amlodipine besylate\ndecreases systemic arterial blood pressure (BP)\nand reduces the prevalence of complications in cats\nwith induced hypertensive renal insufficiency.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201420 cats with partial nephrectomy.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Following reduction in renal mass, 10\ncats were administered 0.25 mg of amlodipine\/kg,\nPO, q 24 h (group A). Ten cats served as a control\ngroup (group C). Systolic BP (SBP), diastolic BP (DBP),\nand mean BP (MBP), physical activity, and pulse rate\nwere measured continuously for 36 days by use of\nradiotelemetric devices.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Compared with values for clinically normal\ncats, SBP, DBP, and MBP were significantly increased\nin cats of group C. Cats in group A had significant\nreductions in SBP, DBP, and MBP, compared with values\nfor cats in group C. Albuminuria but not urine protein-\nto-creatinine ratio was significantly correlated\n( <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.317) with SBP in hypertensive cats.\nPrevalence of ocular lesions attributable to systemic\nhypertension in group C (7 cats) was greater than that\nobserved in group A (2). Two cats in group C were\neuthanatized on day 16 because of nuerologic complications\nattributed to systemic hypertension. One normotensive\ncat in group A was euthanatized because\nof purulent enteritis of unknown cause on day 27.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Amlodipine\nhad an antihypertensive effect in cats with coexistent\nsystemic hypertension and renal insufficiency. Its use\nmay improve the prognosis for cats with systemic\nhypertension by decreasing the risk of ocular injury or\nneurologic complications induced by high BP. 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