{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:29:49Z","timestamp":1787315389098,"version":"build-2736575974"},"reference-count":62,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine effects of cyclophotocoagulation\nvia administration of 100 J with a neodymium:\nyttrium aluminum garnet (Nd:YAG) laser on\ncorneal touch threshold (CTT), intraocular pressure\n(IOP), aqueous tear production, and corneal nerve\nmorphology in eyes of dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201415 dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Noncontact Nd:YAG laser was transsclerally\napplied (10 applications; 25 W for 0.1 seconds for\neach application to each of 4 quadrants) to the ciliary\nbody of the left eye of 15 dogs; the right eye was the\ncontrol eye. Corneal integrity, CTT, tear production as\nmeasured by the Schirmer tear test (STT), and IOP were\nevaluated for 14 days following laser treatment. On day\n14, dogs were euthanatized, eyes harvested, and\ncorneas stained with gold chloride. Major nerve bundles\nwere analyzed by use of a drawing tube attached to a\nlight microscope, and maximum diameters were measured\nby use of image analysis software.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014All laser-treated eyes had significantly higher\nCTT values, compared with control eyes. Six of 15\nlaser-treated eyes developed ulcerative keratitis. On\nmost days, IOP was significantly lower in laser-treated\neyes in both morning and evening. Laser-treated\neyes had a significant decrease of approximately 1\nnerve bundle\/corneal quadrant. Values for STT or\nnerve bundle diameters did not differ significantly.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\n                    \u2014Administration\nof 100 J with a Nd:YAG laser effectively\nreduced IOP while increasing CTT and caused a significant\ndecrease in number, but not diameter, of\nmajor corneal nerve bundles. Nerve damage and\ncorneal hypoesthesia are etiologic factors in ulcerative\nkeratitis following Nd:YAG cyclophotocoagulation.\n(\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2002;63:906\u2013915)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2002.63.906","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T09:52:03Z","timestamp":1135158723000},"page":"906-915","source":"Crossref","is-referenced-by-count":27,"title":["Effects of cyclophotocoagulation with a neodymium:yttrium-aluminum-garnet laser on corneal sensitivity, intraocular pressure, aqueous tear production, and corneal nerve morphology in eyes of dogs"],"prefix":"10.2460","volume":"63","author":[{"given":"Anne Kelley","family":"Weigt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian P.","family":"Herring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl F.","family":"Marfurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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