{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:15:31Z","timestamp":1778544931675,"version":"3.51.4"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine whether a chemokine\n(RANTES)-like protein expressed by ciliary epithelium\nplays a role in uveitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Sample Population<\/jats:bold>\n                    \u20143 clinically normal horses intradermal,\n5 eyes from 5 horses with recurrent uveitis,\nand 10 normal eyes from 5 age- and sex-matched\nhorses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014Cross-reactivity and sensitivity of recombinant\nhuman (rh)-regulated upon activation, normal\nT-cell expressed and secreted (RANTES) protein were\nevaluated in horses by use of intradermal hypersensitivity\nreactions and a chemotaxis assay. Aqueous\nhumor and ciliary body of eyes from clinically normal\nhorses and horses with uveitis were examined for\nRANTES expression by use of an ELISA and reverse\ntranscription-polymerase chain reaction (RT-PCR).\nExpression of RANTES mRNA and protein content of\nprimary cultures of equine ciliary pigmented epithelial\ncells (RT-PCR) and culture supernatant (ELISA) were\nmeasured 6 or 24 hours, respectively, after cultures\nwere stimulated with interleukin-1\u03b2 and tumor necrosis\nfactor-\u03b1.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Strong reactions to intradermal hypersensitivity\ntesting and significant chemotaxis of equine\nleukocytes to rh-RANTES wereas observed. Aqueous\nhumor of eyes from horses with uveitis contained\nincreased concentrations of rh-RANTES-like protein\n(mean \u00b1 SD, 45.9 \u00b1 31.7 pg\/ml), compared with aqueous\nhumor from clinically normal horses (0 pg\/ml).\nCiliary body from horses with uveitis expressed\nRANTES mRNA, whereas ciliary body from clinically\nnormal horses had low mRNA expression. Stimulated\nciliary pigmented epithelial cells expressed increased\namounts of rh-RANTES-like protein (506.1 \u00b1 298.3\npg\/ml) and mRNA, compared with unstimulated samples.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Ciliary epithelium\nmay play a role in recruitment and activation of\nleukocytes through expression of RANTES.\n(\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2002;63:942\u2013947)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2002.63.942","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T13:27:09Z","timestamp":1138022829000},"page":"942-947","source":"Crossref","is-referenced-by-count":19,"title":["Expression of a chemokine by ciliary body epithelium in horses with naturally occurring recurrent uveitis and in cultured ciliary body epithelial 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