{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:36:30Z","timestamp":1788183390068,"version":"build-2803163510"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether oral administration\nof L-lysine to cats would lessen the severity of conjunctivitis\ncaused by feline herpesvirus (FHV-1).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 healthy young adult cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Cats received oral administration of\nlysine monohydrochloride (500 mg, q 12 h) or placebo\n(lactose) beginning 6 hours prior to inoculation of\nvirus. The left conjunctival sac received a 50-\u00b5l suspension\nof FHV-1 grown in cell culture (1.8 X 10<jats:sup>8<\/jats:sup> tissue\nculture infective dose<jats:sub>50<\/jats:sub>) on day 1. Cats were evaluated\nand scores given for clinical signs each day for 21\ndays. Samples for virus isolation were collected from\nthe eye and throat every third day. Plasma lysine and\narginine concentrations were measured prior to the\nstudy and on days 3, 14, and 22.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Cats that received lysine had less severe\nconjunctivitis than cats that received placebo. Virus\nisolation results did not differ between the groups.\nPlasma lysine concentration was significantly higher\nin cats that received lysine, compared with control\ncats, whereas plasma arginine concentrations did not\ndiffer between groups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014Oral administration\nof 500 mg of lysine to cats was well tolerated\nand resulted in less severe manifestations of conjunctivitis\ncaused by FHV-1, compared with cats that\nreceived placebo. Oral administration of lysine may be\nhelpful in early treatment for FHV-1 infection by lessening\nthe severity of disease. 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