{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:35:07Z","timestamp":1763746507955,"version":"3.38.0"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine whether fenbendazole\neffectively eliminates <jats:italic>Giardia<\/jats:italic> organisms from chronically\ninfected cats that have a concurrent\n<jats:italic>Cryptosporidium parvum<\/jats:italic> infection.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201416 clinically normal cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Eight cats with chronic concurrent\n<jats:italic>Giardia<\/jats:italic> and <jats:italic>C parvum<\/jats:italic> infections received fenbendazole\n(50 mg\/kg, PO, q 24 h) for 5 days (treatmentgroup\ncats). Feces from each cat were collected and\nprocessed 3 days weekly for 23 days after treatment.\nBy use of an immunofluorescent assay for detection\nof <jats:italic>Giardia lamblia<\/jats:italic> cysts and <jats:italic>C parvum<\/jats:italic> oocysts, organism\nnumbers were counted and scored. Fecal results\nfrom treatment-group cats were compared with\nthose of 8 untreated cats with <jats:italic>Giardia<\/jats:italic> infection but no\n<jats:italic>C parvum<\/jats:italic> infection (control-group cats).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Four of 8 treatment-group cats had consistently\nnegative results for <jats:italic>Giardia<\/jats:italic> infection after treatment.\nThese 4 cats had consistently positive results\nfor <jats:italic>C parvum<\/jats:italic> oocysts prior to treatment and consistently\nnegative results after treatment. One treatment\n-group cat had positive results for cysts on all fecal\nsamples, and 3 treatment-group cats had 1 to 3 negative\nresults and then resumed shedding large numbers\nof cysts; each of these cats had consistently\npositive results for <jats:italic>C parvum<\/jats:italic> oocysts. When compared\nwith control-group cats, treatment-group cats\nshed less <jats:italic>Giardia<\/jats:italic> cysts during week 1 after treatment\nbut not during week 2.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Administration\nof fenbendazole decreases <jats:italic>Giardia<\/jats:italic> cyst shedding to\nless than detectable numbers in some cats. In our\nstudy, persistent <jats:italic>C parvum<\/jats:italic> infection may have been\nassociated with failure of fenbendazole to eliminate\n<jats:italic>Giardia<\/jats:italic> infection. 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