{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T13:11:46Z","timestamp":1741353106842,"version":"3.38.0"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To investigate the clinicopathologic patterns\nof the erythropoietic response after renal transplantation\nin cats with chronic renal failure (CRF).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201414 cats with CRF undergoing renal transplantation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Before and at intervals during a 6-month\nperiod after transplantation, serum creatinine and erythropoietin\nconcentrations, Hct, erythrocyte indices,\naggregate reticulocyte percentage, and iron variables\nwere measured. Additionally, the number of transfusions\nadministered to and any complications that\ndeveloped in each cat were recorded.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014In all cats, preoperative azotemia resolved\nwithin 6 days after renal transplantation. Two cats had\na temporary increase in serum creatinine concentration\nsecondary to an acute graft rejection episode.\nAnemia (defined as Hct &lt; 28%) resolved in 10 cats 3\nto 49 days after surgery. Resolution of anemia was\ndelayed in 2 cats that had acute rejection episodes.\nSerum erythropoietin concentration and reticulocyte\npercentage were low preoperatively; values after\nsurgery were highly variable. Compared with preoperative\nvalues, serum erythropoietin concentration\nincreased 1 to 4 days after surgery in 11 cats;\nbetween days 5 and 58, another increase was detected\nin 9 cats. Serum iron concentrations were generally\nlow before and 14 days after transplantation.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusion and Clinical Relevance<\/jats:bold>\u2014The erythropoietic\nresponse was highly variable in cats after renal\ntransplantation, but anemia typically resolved within 1\nmonth after surgery. A delay in resolution of anemia in\ncats may indicate poor graft function and inadequate\niron stores, suggesting the need for further evaluation\nfor concurrent illness. 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