{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:10:27Z","timestamp":1781478627323,"version":"3.54.1"},"reference-count":54,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To evaluate progesterone and estrogen\nreceptor expression in meningiomas of the CNS in\ndogs and cats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20148 dogs (1 of which was treated with gestrinone)\nand 5 cats with intracranial meningiomas and 2\ndogs with spinal cord meningiomas; tissue samples\nwere also obtained from 1 clinically normal dog and 1\nclinically normal cat.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Meningioma tissue was obtained during\nsurgery or at necropsy; samples were processed for\nhistologic classification and immunohistochemical\nevaluation of the proportion of tumor cells with progesterone\nand estrogen receptors. Correlation among\nreceptor expression, tumor grade, and histologic subtypes\nwas determined.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Several histologic subtypes of intracranial\nmeningiomas were detected among tissue samples.\nIn the cats, all intracranial meningiomas were benign.\nProgesterone receptor immunoreactivity was detected\nin 14 of 15 meningiomas. Progesterone receptor\nexpression was identified in &gt; 80% of cells in 8\nintracranial meningiomas (4 dogs and 4 cats) and 2\nspinal cord meningiomas. In samples of malignant\ntransitional and granular cell meningiomas in dogs,\nprogesterone receptors were detected in 32 and\n4.8% of cells respectively. In 1 cat, 38% of tumor\ncells had progesterone receptors. In a dog treated\nwith gestrinone, no progesterone receptors were\ndetected in the intracranial meningioma. Estrogen\nreceptors were only detected in the tumor of 1 dog.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicate\na high proportion of progesterone receptors in\ncells of meningiomas of the CNS in dogs and cats.\nAntiprogesterone treatment may have a role in the\ntreatment of unresectable or recurrent meningiomas\nin dogs and cats. (<jats:italic>Am J Vet Res<\/jats:italic> 2003;64:1310\u20131318)<\/jats:p>","DOI":"10.2460\/ajvr.2003.64.1310","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T18:27:20Z","timestamp":1138040840000},"page":"1310-1318","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of progesterone and estrogen receptor expression in 15 meningiomas of dogs and cats"],"prefix":"10.2460","volume":"64","author":[{"given":"P. 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