{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:51:26Z","timestamp":1775742686168,"version":"3.50.1"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine magnitude and duration of\nthe effect of oral administration of methazolamide at\n2 dosages on intraocular pressure (IOP) in dogs in single-\ndose and multiple-dose trials and to determine\naqueous humor flow rate (AHFR) by use of anterior\nsegment fluorophotometry before and during treatment.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201425 healthy adult Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Baseline IOPs and AHFRs were determined\non days 0 and 1, respectively. On day 2, the\nsingle-dose trial was initiated with oral administration\nof 25 or 50 mg of methazolamide at 7 AM to 2 groups\nof 10 dogs each. Five dogs served as controls. In the\nmultiple-dose trial, the same dogs received 25 or 50\nmg of methazolamide at 7 AM and at 3 and 11 PM on\ndays 3 through 9.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Intraocular pressures varied diurnally with\nhighest IOPs in the morning. In the single-dose trial,\nIOP decreased significantly at 3 to 6 hours after treatment\nand then increased significantly at later time\npoints, compared with baseline values. In the multipledose\ntrial, dogs in both treatment groups had significantly\nlower IOPs during the treatment period at 10 AM\nand 1 PM but not at 6 and 9 PM, compared with baseline\nvalues. In both treatment groups morning IOPs\nhad returned to baseline values by the first day after\ntreatment. Evening IOPs were significantly increased\nby 2 to 3 days after treatment, compared with baseline\nvalues. The AHFRs in both treatment groups were significantly\nlower than pretreatment AHFRs.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Oral administration\nof methazolamide decreases IOPs and AHFRs\nin clinically normal dogs, with effectiveness diminishing\nin the evening. 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