{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T13:47:05Z","timestamp":1775742425210,"version":"3.50.1"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To investigate the effects of IM administration\nof acepromazine on indices of relative renal\nblood flow and glomerular filtration rate (GFR) by\nmeans of scintigraphy, as well as the effects on physiologic,\nhematologic, and serum biochemical variables\nin anesthetized dogs, compared with effects of\nadministration of saline.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u20146 healthy Beagles.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Acepromazine (0.1 mg\/kg) or physiologic\nsaline (0.9 NaCl) solution was administered IM 30\nminutes prior to induction of anesthesia with thiopentone;\nanesthesia was maintained with inspired isoflurane\nfor 2.25 hours. Blood gases and circulatory and\nventilatory variables were monitored. Renal function\nwas evaluated by scintigraphic measurements of GFR\nand relative renal blood flow and analyses of serum\nand urine. Statistical analyses used ANOVA or\nFriedman ANOVA.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Values of relative renal blood flow and GFR\nremained high despite low blood pressures. After\nadministration of acepromazine, mean \u00b1 SD arterial\nblood pressure was 66 \u00b1 8 mm Hg during anesthesia;\nthis value was below the threshold (80 mm Hg) for\nrenal autoregulation of GFR. In comparison, mean\narterial blood pressure after administration of saline\nwas significantly higher (87 \u00b1 13 mm Hg). However,\nbetween treatments, there were no significant differences\nin GFR, relative renal blood flow, or other\nindices of renal function.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Measurements\nof renal function and blood flow in dogs during anesthesia\nwith thiopentone and isoflurane did not differ\nsignificantly between treatments, which suggested that\nacepromazine protects renal function despite inducing\nreduction in blood pressure, compared with effects of\nadministration of saline. 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