{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:14:50Z","timestamp":1776442490312,"version":"3.51.2"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To compare the efficacy of calcium disodium\nEDTA (CaNa<jats:sub>2<\/jats:sub>EDTA) and meso-2,3-dimercaptosuccinic\nacid (DMSA) in reducing concentrations of\nlead in selected tissues for use in treatment of calves\nwith experimentally induced lead toxicosis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201419 sexually intact male Holstein calves\nthat weighed 35 to 60 kg.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Calves were randomly assigned to 1 of 5\ntreatment groups: group 1, control calves; group 2,\nlead only; group 3, lead and EDTA; group 4, lead and\nDMSA; and group 5, lead, EDTA, and DMSA. Calves\nin groups 2 to 5 were dosed daily with lead (5 mg\/kg,\nPO) for 10 days. Doses of EDTA (100 mg\/kg) and\nDMSA (25 mg\/kg) were administered IV once daily for\n4 consecutive days beginning on day 11. Effects of the\nchelators on lead concentrations in the liver, kidneys,\ntestes, muscles, bones, and brain were compared\namong the various groups.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Compared with the effects of EDTA, DMSA\ngreatly reduced lead concentrations in renal and\nhepatic tissues. We did not detect significant differences\nfor the effects of EDTA or DMSA on lead concentrations\nin the testes; there was an adverse interaction\nof EDTA with DMSA that caused an increase in\nlead concentrations in the testes.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014DMSA is\nmuch more effective than EDTA in removing lead\nfrom renal and hepatic tissues in calves. Use of\nDMSA in calves with lead intoxication appears to be a\nviable treatment option. Combining DMSA and EDTA\nas a treatment modality in calves did not offer any\nadvantages. 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