{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:58:31Z","timestamp":1791115111110,"version":"4.1.0"},"reference-count":40,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To investigate the possibility that variants\nin the acidic or basic keratin genes or in desmoglein 1\nmay cause the clinical manifestation of familial footpad\nhyperkeratosis in Irish Terriers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201411 dogs belonging to 2 related affected\npedigrees of Irish Terriers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Genomic DNA was extracted from blood\nsamples obtained from each dog. The DNA markers\nlinked to the genes keratin 2, keratin 9, and\ndesmoglein 1 were amplified by use of a polymerase\nchain reaction technique, and length of the products\nwas determined by use of an automatic DNA analyzer.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014All tested markers yielded information.\nNone of the markers (genotype) cosegregated with\nthe clinical status of the dogs (phenotype) in the 2\npedigrees.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Mutations in\nthe genes encoding keratin 2 and 9 as well as\ndesmoglein 1 are highly unlikely to be the primary\ncause of familial footpad hyperkeratosis in Irish\nTerriers. 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