{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:10:00Z","timestamp":1775769000619,"version":"3.50.1"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2003,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To evaluate use of technetium Tc 99m\ndisodium hydroxymethylene diphosphonate (99m-Tc-\nHDP) for assessing fracture healing and 99m-Tc-HDP\nand technetium Tc 99m ciprofloxacin (99m-Tc-CIPRO)\nfor early diagnosis of osteomyelitis in rabbits.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u201432 skeletally mature New Zealand White\nrabbits.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014A femoral fracture defect stabilized with\nbone plates and cortical screws was used.\nScintigraphy was performed 4, 8, 12, and 16 weeks\nafter surgery. The 99m-Tc-CIPRO scan was performed\n48 hours after the 99m-Tc-HDP scan. The\nuptake ratio of the experimental limb to the normal\nlimb was calculated by use of multiple regions of\ninterest. Results of radiography performed to determine\nexternal callus and lysis grade and percentage\ndefect ossification at 16 weeks were compared with\nscintigraphy results.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Infected fractures had a higher uptake ratio\nfor 99m-Tc-HDP and 99m-Tc-CIPRO than noninfected\nfractures. Infected fractures could be differentiated\nfrom noninfected fractures late in healing by use of\n99m-Tc-HDP. Although 99m-Tc-CIPRO was better\nthan 99m-Tc-HDP for identifying infection, there was\na high incidence of false positive and negative results\nwith 99m-Tc-CIPRO. There was an association\nbetween 99m-Tc-HDP uptake ratio and callus formation\nand a good correlation between 99m-Tc-HDP\nuptake ratio and defect ossification after 4 weeks.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u201499m-Tc-HDP\nand 99m-Tc-CIPRO may be useful for diagnosing\nosteomyelitis late in fracture healing; however, false\npositive and false negative results occur. Technetium\nTc 99m disodium hydroxymethylene diphosphonate\nmay be useful for evaluating fracture healing. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2003;64:736\u2013745)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2003.64.736","type":"journal-article","created":{"date-parts":[[2006,1,23]],"date-time":"2006-01-23T13:29:39Z","timestamp":1138022979000},"page":"736-745","source":"Crossref","is-referenced-by-count":7,"title":["Use of scintigraphy for assessment of fracture healing and early diagnosis of osteomyelitis following fracture repair in rabbits"],"prefix":"10.2460","volume":"64","author":[{"given":"Louise L.","family":"Southwood","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris E.","family":"Kawcak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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